Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells

Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30) were used in the screening tests.

Magnesium [II] complexes of schiff bases of two beta- lactum antibiotics: synthesis and spectral characterization

Two Mg [II] complexes have been synthesized by condensing magnesium chloride with schiff bases of two different beta-lactams. In the present study, cephalexin and cefadroxil were the beta-lactams used for the synthesis of complexcs through schiff base formation. The estimation of carbon, hydrogen. nitrogen and sulphur, percentage of magnesium, and measurcments of IR spectra at 400- 4000cm[-1] indicated the formation of coordination compounds. The ratio of 2:1 complex of schiff base ligand to metal was confirmed through Job's of continuous variation. Further characterization of the complexes was carried out using UV spectra, mass spectra and conductance measurement

Synthesis and characterization of some metal chelates of schiff base ligands derived from isatin with ethylenediamine and diethylenetriamin

Synthesis and identification of certain metal chelates of nickel [II], cobalt [II], copper [II] and zinc [II] with some Schiff base ligands derived from isatin with ethylenediamine and diethylene triamine have been done. The chemical formulas, mode of bonding and geometrical structures for the investigated metal chelates have been discussed and reported in terms of microchemical analyses, molar conductivities, magnetic measurements, IR and electronic spectra performed for the obtained metal chelates. It has been found that Ni [II] ion coordinates octahedrally with diethylenetriamine bis [isatin] Schiff base ligand, while it possesses square-planar arrangements with the other ligands. The ligands behave as neutral tri-, tetra- and pentadentate towards the central metal ion. Copper [II] ion forms chelates of square-planar structures. Cobalt [II] chelates are suggested to have Oh and Td geometries, whereas Zn [II] ion tetrahedrally coordinates. Electrolytic nature is suggested for chelates

Effect of temperature, medium, metals and ligand structure on the stability of metal complexes of certain schiff base ligands derived frome ninhydrin and isatin with some substituted hyrazines

Stability constants of Ni2+, Co2+, Cd2+, and Mn2+ complexes with some Schiff base ligands of isatin-semi and thiosemicarbazones, isatin S-methylhydrazine carbodithioate and ninhydrinsemi and thiosemi- carbazones have been determined potentiometrically in different media containing ratios of aquo-organic solvents [ethanol, acetone, dioxane, tetrahydrofuran, dimethyl formamide] at ionic strength u=0.04 mol. dm-3 KCl at different temperatures. The acid dissociation constants of the ligands have been also determined under identical conditions. The results obtained are discussed in terms of the molecular structure of the ligands. The solvent characteristics as well as the nature of central metal ion. It has been found that the stability constant values increase with increasing the organic solvent in the reaction medium and decrease at higher temperatures. Thermodynamic functions [delta G, delta H, delta S] were evaluated and discussed

Synthesis of some new benzimidazole derivatives with evaluation of their antimicrobial activity

A series of N1-p-[2-benzimidazoylamino] benzoyl] N2-arylidene hydrazine [3a-e], pyrazolone 4 pyrazole 5, carbothioamide 6a-c, 1,3,4-thiadiazol 7 and 1,3,4-triazoles 8 were prepared. Some of the new compounds showed considerable antimicrobial activity against Gram +ve, Gram -ve bacteria, yeast and fungi

Synthesis and characterization of oxovanadium [IV] Schiff base complexes: spectral, magnetic and thermal studies

A series of new complexes of oxovanadium [IV] with Schiff bases derived from some aromatic diamines and 2-hydroxynaphthaldehyde was prepared and characterized by elemental analysis, spectral, conductance as well as by magnetic moment measurements. The oxovanadium [IV] complexes formed monomeric or dimeric complexes by ligand bridging. The structures of the complexes were found to depend on the position of the imine group link to the aromatic moiety. The reaction of oxovanadium [IV] complexes with thionyl chloride was also studies. Thermal analysis of some of the prepared complexes was discussed

Synthesis and characterization of some metal chelates of schiff base ligands derived from isatin with ethylenediamine and diethylenetriamine

The synthesis and identification of certain metal chelates of nickel [II], cobalt [II], copper [II] and zinc [II] with some Schiff base lig and s derived from isatin with ethylenediamine and diethylenetriamine have been carried out. The mode of bonding and geometrical structures for the investigated metal chelates have been discussed in terms of microchemical analyses, molar conductivities, magnetic measurements, IR and electronic spectra. Ni [II] ion was found to coordinate octahedrally with diethylenetriamine bis [isatin] Schiff base lig and and possess square-planar arrangements with the other lig and s. The lig and s behaved as neutral tri-, tetra- and pentadentate towards the central metal ion. Copper [II] ion formed chelates of square-planar structures. Cobalt [II] chelates were suggested to have Oh and Td geometries whereas Zn [II] ion had coordinated tetrahedrally. Electrolytic nature was suggested for chelates

Comparative evaluation of determination of beta-lactam intermediates.

The Schiff's base formation between 6-aminopenicillanic acid, 7-aminodesacetoxycephalosporanic acid and 7-aminocephalosporanic acid and p-dimethylaminobenzaldehyde (PDAB) was investigated. The factors that affect the reaction such as concentration of PDAB, time and pH were studied and optimised for estimation of these intermediates.