Study of the possible effects of butorphanol or nalbuphene on ferrokinetic parameters in the rabbit

This work is a trial to clarify the effect of 2 opioid agonist antagonist on different ferrokinetic parameters. The drugs, butorphanol [Stadol] and nalbuphene [Nubain], are easily collected from market, but still their full safety is not sure. Butorphanol induced insignificant changes on serum iron, total iron binding capacity and% saturation of transferrin, and also, no significant changes on red cell count and indices. On the other hand, nalbuphene induced significant changes of the studied parameters. Hence, it was concluded that the second tested drug is less safer from ferrokinetic point of view and may produce iron deficiency anemia