Efeitos do tratamento cronico de ratos com o extrato de Chamaecrista nictans Irwin and Barneby na eliminacao de calculos renais / Effects of chronic treatment of rats with Chamaecrista nictans Irwin and barneby on eliminition of renal calculli

Chamaecrista nictans subs. patellaria var. ramosa Irwin and Barneby (Cassia patellaria DC), tambem conhecida pelo nome popular de peninha, e uma erva daninha originaria do Brasil cujo cha e utilizado na medicina popular para eliminacao de calculos renais. O ensaio farmacologico foi feito a fim de testar o efeito do tratamento cronico com extrato fluido da planta, na urolitiase experimental em ratos atraves da inducao de calculo vesical. Os resultados indicam que o extrato fluido da peninha nao apresentou atividade antilitiasica no modelo experimental testado

Evaluation of Ammannia baccifera Linn. for antiurolithic activity in albino rats.

Ethanolic extract of A. baccifera was tested for its antiurolithic activity in male albino rats. Urinary stones were induced by implantation of zinc discs in the urinary bladder. The stones formed were mainly of magnesium ammonium phosphate with traces of calcium oxalate. Ethanolic extract of A. baccifera (2g/kg/day, po) was found to be effective in reducing the formation of stones as also in dissolving the pre-formed ones. There was a significant increase in the urinary excretion of calcium, magnesium and oxalate, four weeks after implantation of zinc discs. Treatment with A. baccifera has significantly reduced calcium and magnesium levels in the prophylactic group while it has reversed the levels of these ions to normal values in the curative group.