Auer rod-like inclusions in myeloma cells in a patient with IgG multiple myeloma.

Various inclusions have been reported in the past in plasma cells as well as myeloma cells. Most of these represent light chains of immunoglobulins which are concentrated within these cells. Auer rod-like inclusions in myeloma cells have been infrequently reported. They do not influence prognosis in patients with multiple myeloma but are more of a morphological variance. We report a patient of IgG myeloma with auer rod-like inclusions in myeloma cells in the bone marrow aspirates.

Cell Reactions to Metastatic Tumors in the Regional Lymph Nodes: Light and Electron Microscopic Studies

Cell reactions to metastatic tumors in the regional lymph nodes were studied by light and electron microscope in 20 cases; i.e. reactive hyperplasia (3), tuberculosis (3), metastatic carcinomas from the breast (4), from the stomach (2), from the lung (2), metastatic epidermoid carcinoma (2), metastatic malanoma (2), and reticulum cell sarcoma (2). The lymph node response was usually germinal center predominence type and the pyroninophilic cell response was a similar pattern of nonspecific germinal centers with prominent reactive hyperplasia. In two cases of undifferentiated tumors, one from the breast and another from the lung, large numbers of pyroninophilic cells were found within the tumor tissue. However, the majority of lymphoid cells surrounding tumor cell or tumor masses were pyronin negative lymphocytes. Electron microscopic observations revealed that the cells surrounding tumor cells were mostly medium sized lymphocytes, occasionally blast cells and mature plasma cells. The contact border between the tumor cells and the surrounding cells was mostly tight and smooth, but occasionally loose with irregular processes, and widely separated in the case with plasma cells. Degenerative changes of adjacent cytoplasm of either the tumor cells or the lymphocytes were not frequent, but in some instances focal degeneration of adjacent cytoplasm, particularly on the side of the lymphocytes, was noted.