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1.
J Postgrad Med ; 1994 Apr-Jun; 40(2): 65-7
Artículo en Inglés | IMSEAR | ID: sea-116328

RESUMEN

Kupffer cells are major determinants of outcome of liver injury. Their activity was therefore studied in a model of chronic liver disease. The effect of Tinospora cordifolia, an indigenous agent with proven hepatoprotective activity, was evaluated on Kupffer cell function, using carbon clearance test as a parameter. Rats were divided into two major groups. In Gp I which served as normal control t1/2 of carbon was 9.48 +/- 4.14 min. GpII received horse-serum in a dose of 0.5 ml/100 gm b.w. i.p. for a period of 12 weeks and was divided into three sub-groups. In Gp IIA at the end of 12 weeks half-life of carbon was found to be significantly increased to 19.86 +/- 7.95 min (p < 0.01). Indicating suppressed Kupffer cell function in chronic liver damage. In Gp IIB treated with vehicle for 4 more weeks there was significant prolongation of half-life to 38.32 +/- 10.61 min (p < 0.01), indicating perpetuation of damage in absence of damaging agent. Whereas in Gp IIc, treated with Tinospora cordifolia t 1/2 was decreased to 14.24 7.74 min (p < .01), as compared to vehicle control indicating a significant improvement in Kupffer cell function and a trend towards normalization.


Asunto(s)
Análisis de Varianza , Animales , Carbono/farmacocinética , Modelos Animales de Enfermedad , Femenino , Macrófagos del Hígado/fisiología , Fallo Hepático/metabolismo , Masculino , Tasa de Depuración Metabólica , Plantas Medicinales , Ratas
2.
Indian J Physiol Pharmacol ; 1992 Oct; 36(4): 279-81
Artículo en Inglés | IMSEAR | ID: sea-108939

RESUMEN

Wistar strain albino rats of either sex were subjected to acute noise stress (3000 Hz at > 97 dB) for 30 minutes. Carbon clearance test was conducted in noise stressed animals immediately after the stress period. Significant (P < 0.001) increase of the clearance constant K was observed in stressed animals compared to the controls, indicating increased phagocytic activity of the reticuloendothelial system.


Asunto(s)
Animales , Carbono/farmacocinética , Femenino , Masculino , Sistema Mononuclear Fagocítico/metabolismo , Ruido/efectos adversos , Ratas , Ratas Wistar , Estrés Fisiológico/etiología
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