HPTLC-densitometric determination of cetirizine and montelukast analysis in combined tablet dosage forms

A simple, accurate and rapid high performance thin layer chromatography [HPTLC]-densitometric method was developed for separation and determination of cetirizine [CET] as a long acting antihistamine and montelukast [MON] as an antileukotriene in pharmaceutical dosage forms. The compounds were separated on silica gel 60 F[254] HPTLC plates using a mixture of ethyl acetate: methanol: ammonia solution [25%] [14: 3: 2 v/v/v] as mobile phase. The plates were developed vertically up to a distance of 80 mm. Compact spots of both cetirizine [R[f] = 0.30 +/- 0.01] and montelukast [R[f] = 0.52 +/- 0.02] were obtained. UV detection was performed at 230 nm. Quantitative analysis was performed by absorbance densitometry using peak area. The method was validated in terms of linearity, precision, accuracy, limit of detection [LOD], and limit of quantification [LOQ]. The calibration curves were linear in the range of 40-2000 ng spot[-1] for cetirizine and 120-1000 ng spot[-1] for montelukast. For MON, recovery varied in range of 99.20-100.88% with RSD ranging from 1.02 to 1.90% and for CET, recovery varied in range of 98.13-100.05% with RSD ranging from 1.57 to 1.85%. The LODs were found to be 3.94 and 2.08 ng spot[-1] for CET and MON, respectively. It was observed that the proposed HPTLC method could be used for efficient analysis and monitoring of the CET and MON in combined tablet dosage forms, more convenient with better precision and accuracy than HPLC method

Formulation and evaluation of cetirizine dihydrochloride orodispersible tablet

Cetirizine orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. Tablets were prepared using cetirizine along with camphor and mannitol in the proportion of 1:1:1, 1:1:3, and 1:1:6. The flow property of granules was found to be good for the formulation CZ2 [1:1:3]. The hardness and friability of all the formulations were found to be within the standard limit for orodispersible tablets. Disintegration time was found to be rapid in formulation CZ2 [1:1:3].The in vitro dissolution time was found to be 100% in 11 minutes for the formulation CZ2 [1:1:3]

Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form

Fixed dose combination tablets containing ambroxol HCI and cetirizine HCI are clinically used as mucolytic and antiallergic. Several spectrophotometric and HPLC methods have been reported for simultaneous estimation of these drugs with other drugs. The drugs individually and in mixture obeys Beer's law over conc. range 1.2-4.4 micro g/mL for cetirizine HCL and for ambroxol HCL 15-52 micro g/mL at all five sampling wavelengths [correlation coeff. Well above 0.995]. The mean recoveries from tablet by standard addition method were 100.18% [ +/- 2.4] and 100.66% [ +/- 2.31]. The present work reports simple, accurate and precise spectrophotometric methods for their simultaneous estimation from tablet dosage form

Doseamento de dicloridrato de cetirizina por volumetria em maio näo-aquoso e por espectrofotometria no ultravioleta / Analysis of cetirizine dihydrochloride by non-aqueous titration and by ultraviolet spectrophotometry

Dicloridrato de cetirizina, novo anti-histamínico H1, foi doseado volumetricamente em meio anidro com ácido perclórico e por espectrofotometria, em 232 nm. Verificou-se que ambos os métodos säo viáveis e precisos, sendo o doseamento em meio näo-aquoso mais prático por näo requerer instrumental e ser mais rápido e fácil de executar.