Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x]

A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined.

Integrated Whole Body MR/PET: Where Are We?

Whole body integrated magnetic resonance imaging (MR)/positron emission tomography (PET) imaging systems have recently become available for clinical use and are currently being used to explore whether the combined anatomic and functional capabilities of MR imaging and the metabolic information of PET provide new insight into disease phenotypes and biology, and provide a better assessment of oncologic diseases at a lower radiation dose than a CT. This review provides an overview of the technical background of combined MR/PET systems, a discussion of the potential advantages and technical challenges of hybrid MR/PET instrumentation, as well as collection of possible solutions. Various early clinical applications of integrated MR/PET are also addressed. Finally, the workflow issues of integrated MR/PET, including maximizing diagnostic information while minimizing acquisition time are discussed.

In vivo Tracking of Mesenchymal Stem Cells Labeled with a Novel Chitosan-coated Superparamagnetic Iron Oxide Nanoparticles using 3.0T MRI

This study aimed to characterize and MRI track the mesenchymal stem cells labeled with chitosan-coated superparamagnetic iron oxide (Chitosan-SPIO). Chitosan-SPIO was synthesized from a mixture of FeCl2 and FeCl3. The human bone marrow derived mesenchymal stem cells (hBM-MSC) were labeled with 50 microg Fe/mL chitosan-SPIO and Resovist. The labeling efficiency was assessed by iron content, Prussian blue staining, electron microscopy and in vitro MR imaging. The labeled cells were also analyzed for cytotoxicity, phenotype and differentiation potential. Electron microscopic observations and Prussian blue staining revealed 100% of cells were labeled with iron particles. MR imaging was able to detect the labeled MSC successfully. Chitosan-SPIO did not show any cytotoxicity up to 200 microgram Fe/mL concentration. The labeled stem cells did not exhibit any significant alterations in the surface markers expression or adipo/osteo/chondrogenic differentiation potential when compared to unlabeled control cells. After contralateral injection into rabbit ischemic brain, the iron labeled stem cells were tracked by periodical in vivo MR images. The migration of cells was also confirmed by histological studies. The novel chitosan-SPIO enables to label and track MSC for in vivo MRI without cellular alteration.

New metal complexes of semicarbazones derived from para phenylene diamine of NOO/or NO donor sites and their antimicrobial screening

The synthesis and characterization of new Mn[II]. Co[II] Ni[II] and Cu[II] complexes with semicarbazone ligands derived from para phenylene diamine [where L[1] = Semicarbazide-4-yl-benzene-4 [2-hydroxybenzalde-hyde semicarbazone] [SBFIBS], L[2] = Betizene-1, 4-bis-[2-hydroxybenz-aldehyde semicarbazone-4yl] [BBHBS], L[3] = Semicarbazide-4yl-benzene-4 [2-hydroxyacetophen-one-semicarbazone] SBHAS and L[4] = Semicarbazide-4yl-benzene-4 [2-nitrobenzaldehyde semicarbazone] [SBNBS]] are reported. The ligands contain NOO/or NO donor sites. The elemental analysis suggests different stoichiometries 1: 2: 1 and 1: 2 [M: L]. IR spectra data indicate covalent bond through the oxygen atom of the hydroxyl group, coordination of the carbonyl oxygen and the azomethine nitrogen / or nitrogen of the amine group to the metal ion. TGA determined whether the water or solvent molecules are inside or outside the coordination sphere. Magnetic susceptibility and electronic data are in favour of octahedral structures except in the case of Co [II] complexes of ligand BBHBS and SBHAS as they favour the tetrahedral structure. The biological activity of the complexes has been tested. These complexes showed promising antifungal activities