RESUMEN
A 5-year-old child presented with the second episode of meningitis when we started investigating her to find a cause for recurrent episode of meningitis. During this she suffered from a third attack after which she was diagnosed as having isolated C(3) deficiency. She was put on penicillin prophylaxis and vaccinated against encapsulated bacteria, after which she is now doing well.
Asunto(s)
Preescolar , Complemento C3/deficiencia , Femenino , Humanos , Inmunoglobulina A/sangre , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Vacunas contra la Influenza/uso terapéutico , Meningitis/tratamiento farmacológico , Meningitis/etiología , Vacunas Meningococicas/uso terapéutico , Penicilinas/uso terapéutico , Vacunas Neumococicas/uso terapéutico , RecurrenciaRESUMEN
Congenital deficiencies of complement system proteins are rare. A 4-year-old girl was admitted for meningitis. She had had repeated attacks of pneumococcal meningitis and otitis media at the age of 3 years. Analysis of cerebrospinal fluid showed that this meningitis was due to pneumococcal infection. Complement 3 and CH50 values of the proband and her brother were low, while her parents were normal. The patient was given polyvalent pneumococcal and anti-haemophilus vaccines plus ceftriaxone. Recovery was complete after 15 days of antibiotic therapy. This is the first description of a case of recurrent meningitis with C3 and CH50 deficiency in a Turkish family.
Asunto(s)
Preescolar , Complemento C3/deficiencia , Ensayo de Actividad Hemolítica de Complemento , Femenino , Humanos , Meningitis Neumocócica/inmunología , Recurrencia , TurquíaRESUMEN
A 55 years post menopausal lady presented with puffiness of face, and a pruritic urticarial rash over face and upper trunk of one week duration with accompanying dysphagia. Clinical examination revealed an urticarial rash over face and upper trunk, two small ulcers over floor of mouth and evidence of bilateral VIII, IX and Xth cranial nerve palsies. Hypocomplementemia, negative immune profile and evidence of vasculitis on skin biopsy suggested a diagnosis of hypocomplementemic urticarial vasculitis. The patient responded to a course of steroids.
Asunto(s)
Complemento C3/deficiencia , Complemento C4/deficiencia , Enfermedades de los Nervios Craneales/diagnóstico , Diagnóstico Diferencial , Femenino , Humanos , Persona de Mediana Edad , Urticaria/diagnóstico , Vasculitis Leucocitoclástica Cutánea/diagnósticoAsunto(s)
Niño , Complemento C3/deficiencia , Facies , Humanos , Lipodistrofia/diagnóstico , Masculino , Factores Sexuales , SíndromeAsunto(s)
Preescolar , Humanos , Masculino , Complemento C3/deficiencia , Polimorfismo Genético , Anticuerpos/análisis , Formación de Anticuerpos , Transfusión Sanguínea , Factores Quimiotácticos , Proteínas del Sistema Complemento/análisis , Consanguinidad , Heterocigoto , Homocigoto , Inmunidad Celular , Infecciones Bacterianas/etiología , LinajeRESUMEN
Measurements of serum C3 levels by the single radial immunodiffusion method using Helena plates were done in 41 patients with acute poststreptococcal glomerulonephritis and in 25 healthy children. In 28 patients the sequential determination were done until returning the level above normal range. The mean value of serum C3 concentration in this group as a who1e was lower than in the control group and the difference was statistically significant (p < 0.001). The initial reduction of serum C3 concentration did not correlate with the severity of the acute phase of the disease. In those children with acute poststreptococcal glomerulonephritis, serum C3 concentration returned to normal within six weeks.