Central neurotoxicity of gentamicin: Gentamicin induced 'in vitro' Mg2+ depedent ATP ase activity in auditory area of rat brain

The exact mechanism of otoneurotoxicity of gentamicin is unknown. A study was carried out on the auditory cortex of rat brain both 'in vitro' and 'in vivo' following the administration of gentamicin 135 mglkg body weight for 21 days. Interestingly, the Mg2+ dependent ATPase was increased following the intoxication of gentamicin

Central auditory toxicity of sisomicin in guineapigs.

The central auditory toxicity of sisomicin was studied in guineapigs administered sisomicin (135 mg/kg body weight) sc for 10 days. Total lipids, phospholipids and cholesterol were estimated in the pons, inferior colliculus, medial geniculate body and auditory cortex. While the total lipids were increased in a non-preferential manner in all the regions studied, phospholipids and cholesterol levels registered no change. This study suggests the possible central auditory toxicity following sisomicin administration.