RESUMEN
Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section. Histologically, it consists of neurons compactly distributed and filled with a large number of blood vessels and sparse myelinated fibers. This review presents an analysis of this anatomical region, considering what is most recent in the literature. Subthalamic neurons are excitatory and use glutamate as the neurotransmitter. In healthy individuals, these neurons are inhibited by nerve cells located in the side globus pallidus. However, if the fibers that make up the afferent circuit are damaged, the neurons become highly excitable, thus causing motor disturbances that can be classified as hyperkinetic, for example ballism and chorea, or hypokinetic, for example Parkinson disease (PD). The advent of deep brain stimulation has given the subthalamic nucleus great visibility. Studies reveal that the stimulation of this nucleus improves themotor symptoms of PD.
Asunto(s)
Núcleo Subtalámico/anatomía & histología , Núcleo Subtalámico/anomalías , Núcleo Subtalámico/cirugía , Enfermedad de Parkinson , Sustancia Negra/anatomía & histología , Corteza Cerebral/anatomía & histología , Cuerpo Estriado/anatomía & histología , Estimulación Encefálica Profunda/métodos , Globo Pálido/anatomía & histología , Corteza Motora/anatomía & histologíaRESUMEN
Optical coherence tomography (OCT) is a promising medical imaging technique that uses light to capture real-time cross-sectional images from biological tissues in micrometer resolution. Commercially available optical coherence tomography systems are employed in diverse applications, including art conservation and diagnostic medicine, notably in cardiology and ophthalmology. Application of this technology in the brain may enable distinction between white matter and gray matter, and obtainment of detailed images from within the encephalon. We present, herein, the in vivo implementation of OCT imaging in the rat brain striatum. For this, two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were stereotactically implanted with guide cannulas into the striatum to guide a 2.7-French diameter high-definition OCT imaging catheter (Dragonfly™, St. Jude Medical, USA). Obtained images were compared with corresponding histologically stained sections to collect imaging samples. A brief analysis of OCT technology and its current applications is also reported, as well as intra-cerebral OCT feasibility on brain mapping during neurosurgical procedures.
Asunto(s)
Animales , Masculino , Ganglios Basales/anatomía & histología , Diagnóstico por Computador , Tomografía de Coherencia Óptica , Sistemas de Computación/normas , Cuerpo Estriado/anatomía & histología , Estudios de Factibilidad , Ratas Wistar , Técnicas Estereotáxicas , Tomografía de Coherencia Óptica/normasRESUMEN
Las características histoquímicas de la musculatura externa en el esófago de Synbranchus marmoratus, han sido evidenciadas notándose que no existe una división nítida entre las capas musculares circular externa e interna. Las fibras que integran estas capas se caracterizan por tener una actividad oxidativa media y alta ante la reacción enzimática de NADH-TR. La actividad m-ATPasa con preincubaciones alcalinas fue alta en la mayoría de las fibras. Además fibras de pequeño tamaño en la región interna de la musculatura presentaron baja actividad m-ATPasa y alta actividad oxidativa