RESUMEN
The authors report an 11-year-old boy with septicemia and subacute infective endocarditis due to toxigenic-Corynebacterium diphtheriae. The patient had underlying congenital heart disease and incomplete immunization. He presented with fever, epistaxis and congestive heart failure. He received high-dose penicillin therapy and diphtheria antitoxin with clinical improvement. While he was receiving a high dose of penicillin for 1 month he developed a generalized tonic clonic seizure. A computerized tomogram revealed intracerebral and ventricular hemorrhage. Craniotomy with blood clot removal and ventriculostomy drainage were done. He died 2 days later from brain death and cardiovascular failure.
Asunto(s)
Niño , Corynebacterium diphtheriae/aislamiento & purificación , Difteria/etiología , Endocarditis Bacteriana/microbiología , Resultado Fatal , Humanos , MasculinoAsunto(s)
Humanos , Recién Nacido , Lactante , Preescolar , Niño , Difteria , Infecciones por Bacterias Grampositivas , Pediatría , Corynebacterium diphtheriae , Diagnóstico Diferencial , Difteria/diagnóstico , Difteria/epidemiología , Difteria/etiología , Difteria/historia , Difteria/patología , Difteria/terapia , InmunoterapiaRESUMEN
A difteria, embora seja uma das doenças melhor estudadas atualmente, ainda ameaça a populaçao brasileira. A imunizaçao deficiente e a falta de informaçao das equipes médicas em relaçao à sua incidência dificultam o diagnóstico e o tratamento. Os autores discutem a situaçao epidemiológica brasileira e os novos métodos diagnósticos, preciosos e de baixo custo, realizados pelos laboratórios centrais de Saúde Pública.