RESUMEN
Occupational diseases may be defined only medically or scientifically, and even then, their definition is not simple. However, compensable occupational diseases involve the additional layer of legal systems and social welfare policies as well. Their multifaceted nature makes determining the work-relatedness of these diseases more complex. Korea has established standards for the recognition of occupational diseases in Schedule 5 of the Enforcement Decree of the Labor Standards Act, and specific criteria for the recognition of occupational diseases are listed in Schedule 3 of the Enforcement Decree of the Industrial Accident Compensation Insurance Act. The new list of compensable occupational diseases comprises 13 articles as an open-ended system. The newly added articles pertain to lymphohematopoietic (Article 5) and infectious diseases (Article 9), as well as diseases of other target organs. Furthermore, the article on liver diseases (Article 8) has been partially revised. The new act has been changed to clarify the meaning as it has been presented in recent research. It is necessary to achieve agreement among concerned parties, including experts from the legal, medical, and social domains to resolve the issues of work-relatedness, causation, notion of aggravation, and so on for preparing a list and a process that are more reasonable.
Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Benceno/toxicidad , Enfermedades Transmisibles/economía , Dimetilformamida/toxicidad , Enfermedad Hepática Inducida por Sustancias y Drogas/economía , Enfermedades Hematológicas/inducido químicamente , Plomo/toxicidad , Hepatopatías/economía , Enfermedades Profesionales/economía , República de Corea , Tricloroetileno/toxicidad , Cloruro de Vinilo/toxicidad , Indemnización para Trabajadores/economíaRESUMEN
A dimetilformamida é uma substância amplamente utilizada nos dias atuais, apresentando um amplo espectro de aplicações na indústria moderna. Este estudo busca abordar seus efeitos toxicofarmacológicos especificamente sobre o fígado, sua relação com os riscos ocupacionais, as medidas de proteção à saude do trabalhador e as opções terapêuticas atuais.
Asunto(s)
Humanos , Dimetilformamida/farmacología , Dimetilformamida/toxicidad , Hígado/patología , Hepatopatías , Enfermedades Profesionales , Salud Laboral , Medicina del TrabajoRESUMEN
Aborda as características toxicológicas da N,N-dimetilformamida na avaliaçäo da exposiçäo ocupacional
Asunto(s)
Humanos , Dimetilformamida/toxicidad , Enfermedades Profesionales/prevención & controlRESUMEN
Dimethylformamide (DMF) is widely used as a drug solvent. We found DMF to have wide-spread pharmacological effects including depressant effect on CNS evidenced by a decrease in locomotor activity, body and limb tone and rectal temperature, and potentiation of pentobarbitone sleep. A dose-dependent hypotensive effect was seen in cats and rats. In rats, it was partially blocked by atropine and was associated with bradycardia. DMF antagonised the contractions of smooth muscle induced by many agonists. An atropine sensitive spasmogenic effect was observed on rabbit ileum at 20 ml/l and a direct relaxant effect at 50 ml/l. A positive inotropic effect on guinea pig atria was observed with 5 ml/l. The results indicate DMF concentrations that may not perhaps produce 'solvent artifacts' when used as a solvent.