Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein

Abstract We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged male rats for six weeks; control rats received distilled water. Compared to controls, CMP caused decreased body fat and lipid accumulation in liver cells and the platelet count. CMP did not affect basal blood pressure or heart rate in anesthetized rats. Vascular responsiveness to phenylephrine, DL-propargylglycine (PAG), acetylcholine or sodium nitroprusside was unaffected, but vasorelaxation to glyceryl trinitrate (GTN) increased. Effects of ODQ on vasorelaxation to GTN were similar in both groups. Expression of blood vessel eNOS, CSE and sGC was normal. The cyclic guanosine monophosphate (cGMP) level of CMP-treated rats was normal but addition of GTN increased cGMP and NO concentration more in CMP-treated rats than in controls, an effect unaltered by addition of diadzin. Taken together, CMP appears partially responsible for the improvement in cardiovascular health markers caused by coconut milk in middle-aged male rats

História da obesidade na classificação internacional de doenças (CID): de 1900 a 2018 / History of obesity in the international classification of diseases (ICD): 1900 to 2018

O presente artigo teve como objetivo descrever o histórico da inserção da condição clínica denominada atualmente de "obesidade" nas onze revisões da Classificação Internacional de Doenças (CID), publicadas pela Organização Mundial da Saúde (OMS), entre os anos 1900 e 2018. Para tanto, buscou-se pela palavra-chave "obesity" nos documentos, realizando, posteriormente, uma descrição e uma análise da presença, modo de inserção e as mudanças ocorridas ao longo do tempo. Os resultados demonstraram que a condição já foi e continua sendo inserida como sintoma, morbidade, coREVSmorbidade, causa de mortalidade e/ou doença. Concluiu-se que há uma grande inconsistência lógica nos princípios que regem a classificação.

This article aimed at describing the history of insertion of the clinical condition currently referred to as "obesity" in the eleven revisions of the International Classification of Diseases (ICD) published by the World Health Organization (WHO) between 1900 and 2018. For this purpose, a search for the keyword obesity was performed in the documents, with subsequent description and analysis of the presence, mode of insertion, and changes occurring over time. The results demonstrated that the condition has been and continues to be inserted as symptom, morbidity, comorbidity, cause of mortality and/or disease. It can be concluded that there is a massive logical inconsistency in the principles that govern the classification.