Keratosis pilaris and prevalence of acne vulgaris: a cross-sectional study

BACKGROUND: Acne vulgaris has an important genetic predisposition, as well as keratosis pilaris. Clinical observations suggest that patients with keratosis pilaris have less frequent or less severe acne breakouts; however, we found no studies on this regard OBJECTIVE: To determine if the presence of keratosis pilaris is associated with lower prevalence and severity of acne. METHODS: A cross-sectional study was conducted with dermatology outpatients aged between 14 and 35 years. We evaluated history and clinical grade of acne, demographic variables, history of atopy, smoking, and use of hormonal contraceptives. Two groups were defined by the presence or absence of moderate to severe keratosis pilaris on the arms and were compared by bivariate analysis and by conditional multiple logistic regression. RESULTS: We included 158 patients (66% women), with a median age of 23±11 years. Twenty-six percent of them had keratosis pilaris, which was associated with a history of atopy (odds ratio [OR]=2.80 [1.36 to 5.75]; p<0.01). Acne was present in 66% of subjects, and was related to family history of acne (OR=5.75 [2.47 to 13.37]; p<0.01). In bivariate and multivariate analysis, the group with keratosis pilaris had a less frequent history of acne (OR=0.32 [0.14 to 0.70]; p<0.01). CONCLUSION: The presence of moderate to severe keratosis pilaris on the arms was associated with lower prevalence of acne vulgaris and lower severity of facial lesions in adolescents and young adults. .

Doença de Darier / Darier's disease

Os autores relatam casos de doença de Darier em membros de três gerações. Comentam o quadro clínico, métodos de diagnóstico e a terapêutica a ser empregada.

Cases of Darier's disease in members of three generation are related. The authors comment the clinical manifestation, diagnosis and different methods of treatment.

Paquioniquia congênita(Sindrome de Jadassohn Lewandowsky) / Pachyonychia Congenita (Syndrome of Jadassohn Lewandowsky)

A sin drome de jadassohn lewandowsky ou paquioniquia conjenita (PC) hereditaria autossomica dominante de ocorrencia rara com expressividade fenotipica altamente variavel. Caracteriza-se pela formação de quantidades excessivas de queratina nas unhas pele e mucosas, manifestada por hiperceratose ungueal simetrica hiperceratose palmoplantar e leucoceratose folicular. Apresenta-se o caso de um jovem portador dessa anomaliacom onicodistrofa generalizada de mâos e pes, hiperceratose palmoplantar dentes natis maculas no dorso comedões e cistos multiplos pelo corpo paquitriquia e placas alopecias ocipitais. Neste artigo citam-se aspectos geneticos compilam-se manifestações clinicas revisam-se propostas de classificação descreve-se o quadro histologico e aventam-se as possibilidades terapeiticas da PC.