Asunto(s)
Fiebres Hemorrágicas Virales , Fiebre del Valle del Rift , Arenavirus del Nuevo Mundo , Fiebre de Lassa , Enfermedad del Bosque de Kyasanur , Enfermedad del Virus de Marburg , Fiebre Hemorrágica Americana , Fiebre Hemorrágica con Síndrome Renal , Dengue Grave , Fiebre Hemorrágica de Omsk , Fiebre Hemorrágica Ebola , Virus de la Fiebre Hemorrágica de Crimea-CongoRESUMEN
100 cases of Kyasanur Forest Disease were studied clinically and autopsy or postmortem biopsies of various organs were done in 8 cases. 1. Our study showed that KFD passes through 4 stages each lasting for about a week. i.e. a prodromal stage with fever, hypotension hepatomegaly, a stage of complication characterized by haemorrhage, neurological manifestation or bronchopneumonia, a stage of recovery followed by a li stage of fever in some cases. 2. The exact of cause of haemorrhage could not be identified though Disseminated Intravascular Coagulation was suspected. 3. Hypotension in KFD could be of Myocardial origin. 4. Encephalopathy in KFD could be due to a metabolic cause probably of hepatic origin. 5. Lung signs could be due to intraalveolar haemorrhage and secondary infection.
Asunto(s)
Adolescente , Adulto , Anciano , Niño , Preescolar , Brotes de Enfermedades , Femenino , Humanos , India/epidemiología , Lactante , Recién Nacido , Enfermedad del Bosque de Kyasanur/epidemiología , Masculino , Persona de Mediana Edad , Estudios RetrospectivosRESUMEN
Endogenous interferon (IFN) levels were monitored in acute (51) and convalescent phase (19) sera collected from patients suffering from Kyasanur forest disease (KFD). Levels of circulating IFN in the acute samples (GM 216.3 +/- 8.7) collected between 4 to 7 post onset day (POD) were significantly higher (P less than 0.001) than the convalescent samples (GM 13.19 +/- 1.6) collected between 30th to 90th POD. Interferonemia was concomitant with the viraemic phase. Neutralization studies indicated that the endogenous (circulating) IFN was antigenically similar to acid stable form of IFN-alpha.