Manifestaciones neurológicas en una paciente con lupus eritematoso sistémico / Neurological manifestations in a patient with systemic lupus erythematosus

El lupus eritematoso sistémico es una enfermedad inflamatoria sistémica cuyo proceso inflamatorio genera un importante número de manifestaciones clínicas articulares y extraarticulares. Entre las manifestaciones extraarticulares destaca la afectación neurológica, y el compromiso puede ser tanto a nivel del sistema nervioso central o periférico. El objetivo de la presente investigación es presentar el caso de una paciente de 56 años de edad, con diagnóstico de lupus eritematoso sistémico de 18 años de evolución quien presentó un cuadro crónico de cefalea, neuropatía periférica y miastenia gravis como manifestaciones neurológicas de la enfermedad. Con el tratamiento de ciclofosfamida y el aumento de la dosis de esteroide, en la actualidad la paciente se encuentra estable. El reporte de este caso hace hincapié en la importancia que revisten las manifestaciones neurológicas como parte de las manifestaciones extraarticulares de esta enfermedad, ya que este tipo de afección es determinante en el curso del lupus eritematoso sistémico y en la calidad de vida de los pacientes(AU)

Systemic lupus erythematosus is a systemic inflammatory disease whose inflammatory process generates a significant number of articular and extra-articular clinical manifestations. Within the extra-articular manifestations, neurological involvement stands out, among others, the commitment can be both at the level of the central or peripheral nervous system. The objective of the present investigation is to present the case of a 56-year-old patient, diagnosed with systemic lupus erythematosus of 18 years of evolution and who has presented chronic symptoms of headache, peripheral neuropathy and myasthenia gravis as neurological manifestations of the illness. The report of this case is considered important to publicize the importance of neurological manifestations as part of the extra-articular manifestations of this disease; this type of condition is decisive in the course of the disease and in the quality of life of patients(AU)

Esclerodermia localizada en escolar de 10 años / Localized scleroderma in a 10-year-old schoolgirl

Dentro del grupo de enfermedades reumáticas la esclerodermia es una de las de menor frecuencia de presentación, por lo que muchos autores la consideran una enfermedad rara. Aunque afecta predominantemente a pacientes adultos, en ocasiones se presenta en edades pediátricas y sus formas localizadas son las manifestaciones más frecuentes a estas edades. El objetivo del presente reporte es presentar el caso de una escolar de 10 años de edad, con un cuadro de lesión en la piel de 3 años de evolución a la cual se le diagnostica, mediante las características clínicas y los resultados de estudios anatomopatológicos una esclerodermia localizada profunda. En la actualidad la paciente se mantiene en régimen de seguimiento multidisciplinario. Este reporte de caso es importante para compartir con la comunidad médica los elementos básicos relacionados con el diagnóstico y tratamiento de esta enfermedad, como alternativa a la reducción de las complicaciones que genera(AU)

Within the group of rheumatic diseases, scleroderma is one of those with the lowest frequency of presentation; being considered a rare disease by many authors. Although it has a predominance of affectation in adult patients, it sometimes occurs in pediatric ages, its localized forms being the most frequent forms of presentation. The objective of this report is to present the case of a 10-year-old schoolgirl, with a 3-year history of skin lesions, which was diagnosed, through clinical characteristics and results of pathological studies, as deep localized scleroderma. The case report is considered important to share with the medical community the basic elements related to the diagnosis and treatment of this disease, as an alternative to reducing the complications it generates(AU)

Evaluación de la calidad de vida de los pacientes con osteoartritis sintomática de rodilla / Evaluation of the quality of life of patients with symptomatic osteoarthritis of the knee

Introducción: El estudio de la morbilidad y el impacto de la enfermedad en el estilo de vida se conocen como medición de la calidad de vida. Objetivo: Evaluar el nivel de la calidad de vida de pacientes con diagnóstico de osteoartritis sintomática de rodilla. Métodos: Se realizó una investigación descriptiva, transversal, en pacientes con diagnóstico de osteoartritis sintomática de rodilla del Centro de Referencia de Enfermedades Reumáticas entre noviembre de 2017 a junio de 2020. La muestra quedó conformada por 213 pacientes, evaluados con el índice de WOMAC de calidad de vida. Resultados: En el grupo de edad de 55-64 años y discapacidad grave se obtuvo la mayor frecuencia de casos (18,3 por ciento; 39). Los pacientes con sobrepeso y discapacidad grave representaron el 28,2 por ciento (60). Predominaron los que tuvieron más de 5 años de evolución de la enfermedad y discapacidad grave (21,0 por ciento; 45). El mayor porcentaje de pacientes se presentó con deformidad de genu varo y discapacidad grave (29,6 por ciento; 63). Hubo relación entre la calidad de vida y el sexo, el índice de masa corporal y el tiempo de evolución de la enfermedad. Conclusiones: La intensidad del dolor se relaciona con un grado radiográfico avanzado, en tanto la calidad de vida con el sexo, el tiempo de evolución de la enfermedad y el índice de masa corporal(AU)

Introduction: The study of morbidity and the impact of the disease on lifestyle is known as quality of life measurement. Objective: To evaluate the level of quality of life of patients diagnosed with symptomatic osteoarthritis of the knee. Methods: A descriptive, cross-sectional investigation was carried out in patients diagnosed with symptomatic knee osteoarthritis from the Reference Center for Rheumatic Diseases between November 2017-June 2020. The sample was made up of 213 patients, who were evaluated with the WOMAC index of quality of life. Results: In the age group of 55-64 years and severe disability, the highest frequency of cases was obtained (18.3percent; 39). Patients with overweight and severe disability represented 28.2percent60). Those who had more than 5 years of evolution of the disease and severe disability prevailed (21.0percent; 45). The highest percentage of patients presented with genu varus deformity and severe disability (29.6percent; 63). There was a relationship between quality of life and sex, body mass index and the time of evolution of the disease. Conclusions: The intensity of the pain is related to an advanced radiological degree, while the quality of life is related to sex, the time of evolution of the disease and the body mass index(AU)

Rheumatic diseases and associated factors in older adults: a Brazilian populationbased study / Doenças reumáticas e seus fatores associados em idosos: um estudo de base populacional brasileiro

INTRODUCTION: Rheumatic diseases have high occurrence in older adults, which may lead to a reduction in independence and quality of life. OBJECTIVE: To calculate prevalence and to identify factors associated with rheumatic diseases in older adults of the urban area of a municipality in Southern Brazil. METHODS: Cross-sectional population-based study, conducted in 2008 in the city of Bagé-RS, Brazil with older adults aged 60 years or over. The outcome was defined from the question "Has any doctor told you that you have rheumatism, arthritis or arthrosis?" Poisson regression was used for the crude and adjusted analysis. RESULTS: A total of 1,593 participants were interviewed. 27.3% (95% CI 25.0-29.5) reported having medical diagnosis of at least one of the rheumatic diseases studied. In the adjusted analysis, it was found that female sex (RP=2.86; 95% CI 2.28-3.59; p≤0.001), without schooling (RP=1.24; 95% CI 1.0-1.58; p=0.047), not living alone (RP=1.29; 95% CI 1.03-1.61; p=0.024), poor self-perception of health (PR=1.54; 95% CI 1.63-2.02; p=0.001), spinal problems (PR=1,96; 95% CI 1.67-2.31; p≤0.001), fall in the last year (PR=1.22; 95% CI 1.04-1.43; p=0.013), incapacity for instrumental activities of daily living (PR=1.20; 95% CI 1.02-1.41; p=0.028) and healthcare appointment in the last 3 months (PR=1.20; 95% CI 1.01-1.42; p=0.035) were associated with the presence of rheumatic diseases (rheumatism, arthritis and arthrosis). CONCLUSION: It is suggested that care of musculoskeletal problems of the spine should be increased, in order to reduce falls and functional disability in older adults, based on actions focused on the prevention of these problems.

INTRODUÇÃO: As doenças reumáticas têm alta ocorrência na população idosa, o que pode levar à redução da independência e da qualidade de vida. OBJETIVO: Determinar a prevalência e identificar os fatores associados às doenças reumáticas em idosos da zona urbana de um município do Sul do Brasil. MÉTODOS: Trata-se de estudo transversal de base populacional, realizado em 2008 na cidade de Bagé-RS, Brasil, com idosos com 60 anos ou mais. O desfecho foi definido a partir da pergunta "Algum médico já disse que você tem reumatismo, artrite ou artrose?" A regressão de Poisson foi usada para a análise bruta e ajustada. RESULTADOS: Foram entrevistados 1.593 idosos. Destes, 27,3% (IC 95% 25,0-29,5) relataram ter diagnóstico médico de pelo menos uma das doenças reumáticas estudadas. Na análise ajustada, constatou-se que o sexo feminino (RP=2,86; IC 95% 2,28-3,59; p≤0,001), sem escolaridade (RP=1,24; IC 95% 1,0-1,58; p=0,047), não vive sozinho (RP=1,29; IC 95% 1,03-1,61; p=0,024), autopercepção de saúde ruim (RP=1,54; IC 95% 1,63-2,02; p=0,001), problemas de coluna (RP=1,96; IC 95% 1,67-2,31; p≤0,001), queda no último ano (RP=1,22; IC 95% 1,04-1,43; p=0,013), presença de incapacidade para atividades instrumentais de vida diária (RP=1,20; IC 95% 1,02-1,41; p=0,028) e consulta médica nos últimos 3 meses (RP=1,20; IC 95% 1,01-1,42; p=0,035) estiveram associados à presença de doenças reumáticas (reumatismo, artrite e artrose). CONCLUSÃO: Sugere-se que os cuidados com os problemas musculoesqueléticos da coluna devem ser aumentados, a fim de reduzir as quedas e a incapacidade funcional em idosos, com base em ações voltadas para a prevenção desses problemas.

Perda de qualidade do sono e fatores associados em mulheres climatéricas / Loss of quality of sleep and associated factors among menopausal women

Resumo O objetivo deste artigo é identificar a prevalência de perda da qualidade do sono em mulheres climatéricas e os fatores associados. Estudo quantitativo, transversal e analítico, cujas variáveis foram investigadas por questionário estruturado/pré-testado e pelo Índice de Qualidade do Sono de Pittsburgh, em 819 mulheres climatéricas assistidas pela Estratégia Saúde da Família. Regressão de Poisson simples foi utilizada para triagem das variáveis (p < 0, 25). Para a modelagem hierarquizada foi utilizada a regressão de Poisson, adotando nível de significância de 5%. Identificou-se perda de qualidade do sono em 67% da amostra. Variáveis como idade avançada (RP = 1,09; IC = 1,03 - 1,16), sintomas climatéricos moderados e intensos (RP = 1,18; IC = 1,10 - 1,27), ansiedade moderada e grave (RP = 1,17; IC = 1,10 - 1,25), depressão moderada/grave (RP = 1,08; IC = 1,01 - 1,15) e artrite/artrose/reumatismo (RP = 1,07; IC = 1,01 - 1,14) demonstraram associações estatisticamente significativas com a perda de qualidade do sono. A perda de qualidade do sono foi altamente prevalente na população estudada. Os fatores associados à perda da qualidade do sono foram idade avançada, sintomas climatéricos de moderados a intensos, ansiedade e depressão moderada a intensa e presença de artrite/artrose/reumatismo.

Abstract The scope of this article is to identify the prevalence of the loss of quality of sleep and associated factors among menopausal women. It is a quantitative, cross-sectional and analytical study, the variables of which were investigated by applying a structured/pre-tested questionnaire and the Pittsburgh Sleep Quality Index with 819 menopausal women cared for under the Family Health Strategy. Simple Poisson regression was used to screen the variables (p < 0.25). For multiple analysis, Poisson regression was used based on a hierarchical model, at a significance level of 5%. Loss of quality of sleep was identified in 67% of the sample. Variables such as advanced age (PR = 1.09; CI = 1.03-1.16), moderate and severe menopausal symptoms (PR = 1.18; CI = 1.10-1.27), moderate to severe anxiety (PR = 1.17; CI = 1.10-1.25), moderate to severe depression (PR = 1.08; CI = 1.01-1.15) and arthritis/arthrosis/rheumatism (PR = 1. 07; CI = 1.01 - 1.14) revealed statistically significant associations with loss of quality of sleep. The loss of quality of sleep was highly prevalent in the population studied. Factors associated with loss of quality of sleep were advanced age, moderate to severe menopausal symptoms, moderate to severe anxiety and depression, and the presence of arthritis/arthrosis/rheumatism.

Early detection of poor adherence to treatment of pediatric rheumatic diseases: pediatric rheumatology adherence questionnaire - a pilot study / Detecção precoce da má adesão ao tratamento em doenças reumáticas pediátricas: questionário de adesão em reumatologia pediátrica - estudo piloto

ABSTRACT Objective: To develop a questionnaire that allows the early detection of patients at risk for poor adherence to medical and non-medical treatment in children and adolescents with chronic rheumatic diseases. Methods: The Pediatric Rheumatology Adherence Questionnaire (PRAQ) was applied in recently diagnosed patients within a period of one to four months after confirmation of the rheumatic disease. After six months, the patients' adherence to the medical and non-medical treatment was assessed. An internal consistency analysis was conducted to eliminate redundant questions in the PRAQ. Results: A total of 33 patients were included in the pilot study. Six months after the PRAQ had been applied, poor global adherence was observed in seven (21.2%) patients and poor adherence to medical treatment in eight (24.2%) patients. No correlation was observed between the PRAQ scores and the percentages of adherence, as well as the stratification for each index, except for a tendency to a correlation between socioeconomic index and poor adherence to medical treatment (p=0.08). A new PRAQ questionnaire with 25 of the 46 original questions was generated as a result of the reliability analysis. Conclusions: The usefulness of this questionnaire in clinical practice should be still evaluated. Due to the importance of a tool for the early detection of rheumatic patients at risk of poor adherence to treatment, the new PRAQ questionnaire should be reviewed and applied in a larger study to better define its validity and reliability.

RESUMO Objetivo: Desenvolver um questionário que permitisse a detecção precoce de pacientes em risco de má adesão ao tratamento medicamentoso e não medicamentoso para crianças e adolescentes com doenças reumáticas crônicas. Métodos: O Questionário de Adesão em Reumatologia Pediátrica (QARP) foi aplicado em pacientes recentemente diagnosticados, de um a quatro meses após a confirmação da doença reumática. Seis meses depois, foi avaliada a adesão do paciente ao tratamento medicamentoso e não medicamentoso. Foi realizada uma análise de consistência interna para eliminar questões redundantes no QARP. Resultados: Ao todo, 33 pacientes foram incluídos no estudo-piloto. Seis meses após a aplicação do QARP, observou-se baixa adesão global em sete pacientes (21,2%) e baixa adesão ao tratamento medicamentoso em oito (24,2%) pacientes. Não foi encontrada correlação entre os escores QARP e as porcentagens de adesão, bem como a estratificação para cada indicador, com exceção de uma tendência a uma correlação entre o indicador socioeconômico e a baixa adesão ao tratamento medicamentoso (p=0,08). Um novo questionário QARP com 25 das 46 perguntas originais foi gerado como resultado da análise de confiabilidade. Conclusões: A utilidade deste questionário na prática clínica ainda deve ser avaliada. Devido à importância de uma ferramenta para a detecção precoce de pacientes reumáticos em risco de má adesão ao tratamento, o novo questionário QARP deve ser revisado e aplicado em um estudo maior para que sua validade e confiabilidade sejam mais bem definidas.

Rheumatological manifestations associated with viral Hepatitis B or C

Abstract INTRODUCTION Rheumatological findings and rheumatic diseases may be associated with hepatitis virus infection. This study assessed the frequency of these manifestations in a reference unit in Acre, Brazil. METHODS This was a cross-sectional study with a convenience sample of patients having their first consultation at the rheumatology outpatient clinics of a referral unit in Rio Branco, Acre, from March to November 2017. Sociodemographic, clinical, laboratory, and imaging data registereds using a standardized questionnaire form. RESULTS Among the 600 patients with rheumatic complaints, 3.0% were newly diagnosed with hepatitis B virus (HBV) or hepatitis C virus (HCV), and 8.7% were previously diagnosed with hepatitis. Among the 70 patients with hepatitis, 54.3% were carriers of HBV and 45.7% of HCV. For patients infected with HBV and HCV, arthralgia was the most prevalent rheumatic manifestation in 97.4% and 90.6%, followed by myalgia in 81.6% and 65.6%, and arthritis in 26.3% and 40.6% of patients, respectively, according to the descriptive analysis performed using the Statistical Package for the Social Sciences software. In comparative analyses using the chi-squared test, despite the fact that fibromyalgia was the most prevalent rheumatic disease only the Rheumatoid Arthritis there were differences in distribution between the carriers of HCV (18.8%) and HBV (2.6%). According to the Fisher's exact test, hypothyroidism was the most frequent comorbidity in patients with HCV (21.9%). CONCLUSIONS An increased frequency of musculoskeletal manifestations, better than those reported in the medical literature, in patients infected with HBV and HCV was observed.

Associação entre doenças crônicas e força de preensão manual de idosos residentes em Florianópolis - SC, Brasil / Association between chronic diseases and handgrip strength in older adults residents of Florianópolis - SC, Brazil

Resumo O objetivo deste artigo é verificar a associação entre doenças crônicas e força de preensão manual (FPM) em idosos de Florianópolis, SC. Análise transversal de um estudo longitudinal de base populacional, com 599 idosos avaliados. A FPM foi verificada por meio de dinamômetro. As variáveis independentes incluíram 10 doenças crônicas e quedas. Foram realizadas análises de regressão linear simples e múltipla. No modelo final, a artrite/reumatismo/artrose (β:-1,27; IC95%: -2,55;-0,20) foi associada à menor FPM, enquanto a bronquite/ asma (β:1,61; IC95%:0,21;3,00) foi associada à maior FPM, nas mulheres. Para os homens, no modelo final, diabetes (β:-3,78; IC95%:-6,51;-1,05) mostrou associação com a menor FPM. Na análise de tendência, houve declínio da FPM com o aumento do número de doenças crônicas para ambos os sexos. Houve associação entre algumas doenças crônicas e a FPM, com diferenças entre os sexos. Torna-se imprescindível a reformulação de políticas de saúde direcionadas à manutenção da independência e autonomia da população idosa.

Abstract This paper aims to verify the association between chronic diseases and handgrip strength (HS) in the older adults of Florianópolis, SC. This is a cross-sectional analysis of a longitudinal population-based study. HS was measured by dynamometer. Independent variables included 10 chronic diseases and falls. Simple and multiple linear regression analyses were performed. In the final model, in women, arthritis/rheumatism/arthrosis (β: -1.27; 95%CI: -2.55; -0.20) was associated with lower HS and bronchitis/ asthma (β: 1.61, 95%CI: 0.21; 3.00) was associated with higher HS. Regarding men, in the final model, diabetes (β:-3.78; 95%CI: -6.51; -1.05) was associated with lower HS. The trend analysis evidenced a lower HS with increased number of chronic diseases in both genders. There was an association between some chronic diseases and HS, with differences between genders. ĩt is essential to overhaul health policies aimed at maintaining the independence and autonomy of the older adults population.

Chronic joint symptoms in adults: A population-based study / Sintomas articulares crônicos em adultos: um estudo de base populacional

Summary Objective: To analyze factors associated with chronic joint symptoms (CJS) in adults. Method: A population-based, cross-sectional study was performed with a sample of 1,217 adults aged between 20 and 59 years, in the city of Viçosa, in 2014. The sampling process was performed by conglomerates and sample was selected using a two-stage cluster-sampling scheme. First, 30 of the 99 census tracts of Viçosa were randomly selected using a random sampling scheme, without replacement. Household questionnaires were applied to obtain CJS data, sociodemographic conditions, behavioral factors and health status. Multivariable analysis was conducted using Poisson regression, adjusted for the sampling design effect, using the svy commands in Stata software. Results: Prevalence of CJS totaled 31.27%, significantly higher in women (18.45). Age ranges 40-49 (PR 1.50; 95CI 1.16-1.92) and 50-59 years (PR 1.55; 95CI 1.07-2.25); overweight (PR 1.60; 95CI 1.28-2.00); obesity (PR 1.60; 95CI 1.11-2.29); and those who self-reported performing heavy work (PR 1.27; 95CI 1.09-1.48) showed higher prevalences of CJS. Conclusion: Women and individuals who were older, overweight and performing heavy work had a higher risk of CJS in this adult population residing in Viçosa, MG, Brazil.

Resumo Objetivo: Analisar os fatores associados aos sintomas articulares crônicos (SAC) em adultos. Método: Trata-se de um estudo transversal, de base populacional, com 1.217 adultos, na faixa etária de 20 a 59 anos, na cidade de Viçosa, MG, 2014. A amostragem foi realizada por conglomerados em duplo estágio, sendo as unidades de primeiro estágio os setores censitários, e, em seguida, os domicílios. Foram sorteados 30 setores dentre os 99 de Viçosa, por meio de amostragem casual simples, sem reposição. A coleta de dados foi composta por aplicação de questionário contendo questões relativas a variáveis de SAC, sociodemográficas, comportamentais e de saúde. Para verificar as associações, apresentaram-se proporções, razões de prevalência e seus respectivos intervalos de confiança de 95%. A análise múltipla foi realizada por meio da regressão de Poisson, utilizando o conjunto de comandos svy do software Stata, o qual considera o efeito da expansão da amostra na análise dos dados. Resultados: A prevalência estimada de SAC foi de 31,27%, maior nas mulheres (18,45%). Estiveram associadas ao SAC as mulheres (RP 1,49; IC95% 1,23-1,81); as idades de 40 e 49 (RP 1,50; IC95% 1,16-1,92) e 50 e 59 anos (RP 1,55; IC95% 1,07-2,25); o sobrepeso (RP 1,60; IC95% 1,28-2,00); a obesidade (RP 1,60; IC95% 1,11-2,29); e aqueles que autorreferiram realização de trabalho pesado (RP 1,27; IC95% 1,09-1,48). Conclusão: O sexo feminino, a faixa etária de 40 a 59 anos, o sobrepeso, a obesidade e a realização de trabalho pesado foram fatores de risco para SAC em adultos de Viçosa, MG.

Association between demyelinating disease and autoimmune rheumatic disease in a pediatric population / Associação entre doença desmielinizante e doença reumática autoimune em uma população pediátrica

ABSTRACT Introduction: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are demyelinating diseases of the central nervous system. Autoimmunity in patients with demyelinating disease and in their families has been broadly investigated and discussed. Recent studies show a higher incidence of rheumatic autoimmune diseases among adult patients with MS or NMO and their families, but there are no studies in the pediatric population. Objective: To evaluate an association of MS and NMO with autoimmune rheumatic diseases in pediatric patients. Method: 22 patients younger than 21 years old with MS or NMO diagnosed before the age of 18 years were evaluated regarding epidemiological data, clinical presentation, association with autoimmune diseases, family history of autoimmune diseases, laboratory findings, imaging studies and presence of auto-antibodies. Results: Among the patients studied, there was a prevalence of females (68.1%). The mean age of symptoms onset was 8 years and 9 months and the mean current age was 16 years and 4 months. Two patients (9%) had a history of associated autoimmune rheumatic disease: one case of juvenile dermatomyositis in a patient with NMO and another of systemic lupus erythematosus in a patient with MS. Three patients (13%) had a family history of autoimmunity in first-degree relatives. Antinuclear antibody was found positive in 80% of patients with NMO and 52% of patients with MS. About 15% of antinuclear antibody-positive patients were diagnosed with rheumatologic autoimmune diseases. Conclusion: Among patients with demyelinating diseases diagnosed in childhood included in this study there was a high frequency of antinuclear antibody positivity but a lower association with rheumatologic autoimmune diseases than that observed in studies conducted in adults.

RESUMO Introdução: Esclerose múltipla (EM) e neuromielite óptica (NMO) são doenças desmielinizantes do sistema nervoso central. A autoimunidade entre pacientes com doenças desmielinizantes e seus parentes tem sido amplamente investigada e discutida. Estudos recentes demonstram maior incidência de doenças reumáticas autoimunes entre pacientes adultos com EM e NMO e seus parentes, mas não há estudos na população pediátrica. Objetivo: Avaliar a associação de EM e NMO com doenças reumáticas autoimunes em pacientes pediátricos. Método: Foram incluídos 22 pacientes menores de 21 anos com diagnóstico de EM ou NMO antes dos 18 anos e avaliados dados epidemiológicos, clínicos, associação com doenças autoimunes, história familiar de doenças autoimunes, exames laboratoriais, exames de imagem e presença de autoanticorpos. Resultados: Entre os pacientes estudados, houve prevalência do sexo feminino (68,1%). A média de idade de início dos sintomas foi de oito anos e nove meses e a média de idade dos pacientes na avaliação foi 16 anos e quatro meses. Dois pacientes (9%) apresentaram doença reumática autoimune associada, um caso de dermatomiosite juvenil em paciente com NMO e outro de lúpus eritematoso sistêmico juvenil em paciente com EM. Três pacientes (13%) apresentaram história familiar de autoimunidade em parentes de primeiro grau. Anticorpo antinuclear (ANA) positivo foi encontrado em 80% dos pacientes com NMO e em 52% dos pacientes com EM. Cerca de 15% dos pacientes com ANA positivo apresentaram diagnóstico definitivo de doença autoimune reumática associada. Conclusão: Entre os pacientes com doenças desmielinizantes diagnosticadas durante a infância incluídos nesta pesquisa houve uma alta frequência de ANA positivo, mas uma menor taxa de associação com doenças reumáticas autoimunes do que a encontrada em trabalhos conduzidos em adultos.

Autopercepção da saúde em idosos institucionalizados / Self-perceived health in institutionalized elderly

Resumo Este trabalho objetivou determinar a autopercepção da saúde em idosos institucionalizados, assim como verificar a prevalência de percepção negativa da saúde e seus fatores associados. Trata-se de estudo transversal realizado em 10 instituições de longa permanência para idosos (ILPI) da cidade de Natal, entre outubro e dezembro de 2013. Foram analisadas variáveis sociodemográficas, relacionadas à ILPI e às condições de saúde. Realizou-se a análise descritiva, bivariada mediante os testes qui-quadrado, exato de Fisher ou qui-quadrado de tendência linear, assim como multivariado mediante regressão logística. A amostra foi de 127 idosos. A prevalência de autopercepção negativa da saúde foi de 63,19% (IC 95%: 55,07-70,63), e esteve associada à perda de peso (RP: 1,54; IC 95%: 1,19-1,99), doença reumática (RP: 1,46; IC 95%: 1,05-2,01) e ILPI sem fins lucrativos (RP: 1,37; IC 95%: 1,03-1,83), ajustado por sexo. É fundamental desenvolver ações de promoção da saúde nas ILPI, como aquelas baseadas na nutrição e fisioterapia que atuem sobre esses agravos à saúde, com vistas a melhorar a qualidade de vida.

Abstract This study aimed to verify health self-perception, its prevalence and associated factors in institutionalized elderly. A cross-sectional study is presented herein, conducted in 10 Long-Term care Institutions for the Elderly (LTIE) in the city of Natal (Northeast Brazil), between October and December 2013. Sociodemographic variables were analyzed, along with institution-related and health state variables. Descriptive and bivariate analyses were carried out (Chi-squared test, Fisher’s exact test or linear trend Chi-squared test), as well as multivariate analysis (logistic regression). The final sample consisted of 127 elderly. The prevalence of negative self-perceived health was 63.19% (CI 95%: 55.07-70.63), and was associated with weight loss (PR: 1.54; CI 95%: 1.19-1.99), rheumatic disease (PR: 1.46; CI 95%: 1.05-2.01) and not-for-profit LTIE (PR: 1.37; CI 95%: 1.03-1.83), adjusted by sex. More than half of the elderly reported negative self-perceived health, which was associated with weight loss, rheumatic disease and type of institution. Actions must be developed to promote better health conditions in LTIE, such as nutrition consulting and physical therapy, to improve quality of life.

Rheumatology in India: a Bird's Eye View on Organization, Epidemiology, Training Programs and Publications

India is home to the world's second largest population. Rheumatology is an emerging specialty in India. We reviewed organization, epidemiology and training facilities for Rheumatology in India. Also, we also looked at publications in the field of rheumatology from India from over the past six years using Scopus and Medline databases. Despite rheumatologic disorders affecting 6%-24% of the population, rheumatology in India is still in its infancy. Till recently, there were as few as two centers in the country training less than five fellows per year. However, acute shortage of specialists and increasing patient numbers led to heightened awareness regarding the need to train rheumatologists. Subsequently, six new centers have now started 3-year training programs in rheumatology. The epidemiology of rheumatic diseases in India is being actively studies under the Community Oriented Programme for Control of Rheumatic Diseases (COPCORD) initiative. The most number of publications on rheumatic diseases from India are on rheumatoid arthritis, lupus and osteoporosis, many of which have been widely cited. Major collaborators worldwide are USA, UK and France, whereas those from Asia are Japan, Saudi Arabia and Singapore. The Indian Rheumatology Association (IRA) is the national organization of rheumatologists. The flagship publication of the IRA, the Indian Journal of Rheumatology, is indexed in Scopus and Embase. To conclude, rheumatology in India is an actively expanding and productive field with significant contributions to world literature. There is a need to train more personnel in the subject in India.

prevalence and the determinants of musculoskeletal diseases in emiratis attending primary health care clinics in Dubai

Objectives: To estimate the prevalence of rheumatic diseases in the Emiratis attending primary health care [PHC] clinics in Dubai. The secondary objective was to study the relationship between age, gender, and body mass index [BMI] and rheumatic diseases in the general population

Methods: The Prevalence of Rheumatic Diseases and Osteoporosis [PRO] in Dubai study was a cross-sectional study, which randomly enrolled Emiratis' aged between 18-85 years old who attended one of 13 PHC clinics between 2 January 2009 and 31 December 2009. Demographic and health data for all participants was obtained via a questionnaire. Participants that indicated positive answers had their responses validated by a rheumatologist and underwent a thorough locomotor examination

Results: The study included 3,985 participants with a mean age of 42.1 +/- 15.8 years. The majority [77.4%] were female. Lower back pain was the most prevalent problem in our study population [32.9%]. Knee osteoarthritis [OA] was the most common form of arthritis seen in our cohort [25.8%]. Overall, the prevalence of inflammatory arthritis was 3.1%. Age and BMI were associated with increased risk of knee OA and lower back pain

Conclusions: Rheumatic diseases are quite common in Emirati patients attending PHC clinics. Lower back pain and knee OA were the most common musculoskeletal diseases seen in our cohort. There is a need for more populationbased studies in the Middle East to have a better understanding of the epidemiology of rheumatic diseases in this region

Incidência de neoplasias nas doenças reumatológicas autoimunes mais prevalentes: uma revisão sistemática / Incidence of neoplasms in the most prevalent autoimmune rheumatic diseases: a systematic review

O presente artigo é uma revisão sistemática da literatura que aborda a coexistência de neoplasias e doenças reumatológicas autoimunes, suas principais associações, tipos de cânceres e os possíveis fatores de riscos associados, com ênfase nos estudos de base populacional existentes, além de verificar a relação dessa ocorrência com o uso dos fármacos utilizados no tratamento de doenças autoimunes. Foi realizada uma busca de artigos científicos indexados na Cochrane/BVS, Pubmed/Medline e Scielo/Lilacs no período de 2002 a 2012. Também foi consultada a IBICT (biblioteca digital brasileira de teses e mestrados), com os descritores em português e inglês para as palavras: "Esclerose sistêmica", "Artrite reumatoide", "Lúpus Eritematoso Sistêmico" e "Síndrome de Sjögren", correlacionando cada um com o descritor AND "neoplasias". Os resultados mostraram que, na base de dados IBICT, preencheram os critérios de inclusão uma tese e uma dissertação para o descritor LES, nenhuma para AR e uma tese para SS. Na base de dados Lilacs/Scielo foram encontrados dois artigos sobre "Artrite Reumatoide" AND "neoplasias". No Pubmed/Medline, a busca inicial resultou em 118 artigos; destes, preencheram os critérios e foram secionados 41 artigos. Esta revisão observou relação entre neoplasias e as doenças reumatológicas autoimunes, tanto como fator de risco quanto de proteção, embora os mecanismos fisiopatológicos não estejam totalmente elucidados.

This article is a systematic review of the literature about the coexistence of cancer and autoimmune rheumatic diseases, their main associations, cancers and possible risk factors associated, with emphasis on existing population-based studies, besides checking the relation of this occur with the use of the drugs used in the treatment of autoimmune diseases. A search was conducted of scientific articles indexed in the Cochrane / BVS, Pubmed / Medline and Scielo / Lilacs in the period from 2002 to 2012. Also consulted was the IB-ICT (Brazilian digital library of theses and Masters), with descriptors in Portuguese and English for "Systemic sclerosis", "Rheumatoid Arthritis", " Systemic Lupus Erythematosus" and "Sjögren's syndrome", correlating each one with the descriptor AND "neoplasms". The results showed that in the database IBICT a thesis and a dissertation for the descriptor SLE met the inclusion criteria, none met RA one thesis to SS. Lilacs in the database/Scielo found two articles on "Rheumatoid Arthritis" AND "neoplasms". In Pubmed/Medline the inicial search resulted in 118 articles, and 41 were selected. The review noted the relationship between cancer and autoimmune rheumatic diseases, as well as a risk factor for protection, although the pathophysiological mechanisms are not known.

Aspectos atuais da doença reumática / Current aspects of the rheumatic fever

O autor faz revisão sobre a Doença Reumática, frente à sua permanência nas regiões mais pobres do país. Da análise da tríade produtora da enfermidade, discute aspectos ligados aos aspectos imunitários envolvidos, a possibilidade de cepa estreptocócica de grande virulência na gênese de formas graves e, sobretudo, aspectos ligados à pobreza e ausência de saneamento nos locais em que vivem os enfermos. Sob o ângulo clínico, mostra a contradição entre "aspectos atuais da doença", quando eles apenas reproduzem a apresentação que existia nos países centrais nos séculos 18 e 19. Enfatiza a relevância do uso do Ecodopplercardiograma no estudo de populações, o que depõe por prevalência bem maior que estudos realizados apenas com o estetoscópio. Salienta a supremacia da prevenção da doença e a necessidade que seja ela incluída entre as doenças negligenciadas, na base de políticas de combate a essas enfermidades.

The author's review of the Rheumatic Fever, outside hispersistence in the poorest regions of the our country. Analysis of the epidemiological triad of the disease, the aspects immunological are argued, also the possibility of large strain streptococcus virulence in the genesis of serious issues and especially the relevance of the poverty and lack of sanitation inplaces where the sick live. Under the clinical angle shows the contradiction between "current aspects of the disease" when they merely reproduce the presentation that existed in the central countries in the 18th and 19th centuries. Emphasizes the importance of using Doppler echocardiogram in study populations, which argues for much greater prevalence than studies only with the stethoscope. Underlines the primacy of disease prevention and the need to be included it among the neglected diseases, on the basis of policies to combat these diseases.

Mortalidad en enfermedades reumáticas / Mortality in rheumatic diseases

Las enfermedades reumáticas son enfermedades raras, la prevalenciamundial es de 0.3 a 2.1. Las complicaciones en los pacientes reumáticos son dolor crónico y discapacidad, pero cuando estas son agresivas pueden llevarlos a lamuerte. La mortalidad es el reflejo de la severidad de la enfermedad. Hay pocosestudios sobre la mortalidad en estas enfermedades, está descrita de formaindividual y varía de acuerdo a la población estudiada. El objetivo principal de este estudio es caracterizar las causas de muerte en pacientes con enfermedades reumáticas. La causa principal de muerte fue infección; aislando el microorganismo nosocomial en 38%, siendo ésta relacionada de forma indirecta con la enfermedad reumática de base. La mortalidad secundaria a complicacionesde la actividad de la enfermedad fue de 13.43% principalmente en pacientes conlupus eritematoso sistémico (LES) y dermatomiositis. El 48% de los fallecidostenían diagnóstico de LES. Los que recibieron ciclofosfamida y corticoesteroides vía oral y endovenosa a dosis mayor de 50 mg/día presentaron riesgo mayor de fallecer.

Avaliação de entesopatia em pacientes com fibromialgia por meio do novo índice ultrassonográfico de entesite / Assessment of enthesopathy in patients with fibromyalgia by using new sonographic enthesitis index

OBJETIVO: Determinar a frequência de entesopatia na fibromialgia (FM) utilizando um método de ultrassonografia (US) recém-desenvolvido, o escore Madrid Sonography Enthesitis Index (MASEI). MÉTODOS: Este estudo foi realizado em 38 pacientes com FM consecutivos e 48 controles saudáveis pareados para idade e sexo. Seis sítios de ênteses (tuberosidade do olécrano, polos superior e inferior da patela, tuberosidade tibial, polos superior e inferior do calcâneo) nos dois membros inferiores foram avaliados. Todos os achados da US foram identificados de acordo com o escore MASEI. Os escores de pacientes e controles foram comparados usando-se o teste t de Student e o teste U de Mann-Whitney. A validade foi analisada pela curva receiver operating characteristic (ROC). Valores de P < 0,05 foram considerados significativos. RESULTADOS: O escore total de entesite foi 7,39 ± 4,99 (média ± DP) para os pacientes com FM e 3,7 ± 3,22 para os controles saudáveis (P < 0,001). A curva ROC estabeleceu um escore de US > 3,5 no grupo de FM como o melhor ponto de corte para diferenciar casos de controles. Não houve correlação estatisticamente significativa entre o escore MASEI e a duração da FM, e a localização dos pontos dolorosos. CONCLUSÕES: Erros no diagnóstico de FM são prejudiciais aos pacientes e à comunidade, e a presença de entesopatia entre pacientes com FM é crescente. Sua detecção por meio do escore MASEI pode ser útil para discriminar pacientes com FM, cujos sintomas e sinais são mal definidos, para evitar equívoco de tratamento.

OBJECTIVE: The aim of the present study is to determine the frequency of enthesopathy in fibromyalgia (FM) by using a newly developed ultrasonography (US) method, the Madrid Sonography Enthesitis Index (MASEI). METHODS: This study was conducted on 38 consecutive patients with FM and 48 healthy sex- and age-matched controls. Six entheseal sites (olecranon tuberosity, superior and inferior poles of patella, tibial tuberosity, superior and inferior poles of calcaneus) on both lower limbs were evaluated. All US findings were identified according to MASEI. Scores of patients and controls were compared by Student's t-test and Mann-Whitney U-test. Validity was analysed by receiver operating characteristic curve. Values of P < 0.05 were considered significant. RESULTS: Total enthesitis score was 7.39 ± 4.99 (mean ± SD) among FM patients and 3.7 ± 3.22 among healthy controls (P < 0.001). The receiver operating characteristic curve established an ultrasound score of > 3.5 in the FM group as the best cut-off point to differentiate between cases and controls. No statistically significant correlation was found between the MASEI score and the FM disease duration, and the location of the tender points. CONCLUSIONS: Misdiagnoses of FM are harmful to patients and the community, and the presence of enthesopathy among FM patients increases. Its detection with the MASEI score may help to discriminate FM patients presenting with ill-defined symptoms and signs, in order to prevent mistreatment.

Prevalencia de intervenciones de terapia ocupacional en un hospital de agudos / Prevalence of occupational therapy interventions in an acute hospital

El objetivo del presente trabajo consiste en conocer el proceso de tratamiento de terapia ocupacional en las áreas de consultorios externos de reumatología e internación de Clínica Médica y Unidad de terapia intermedia del Hospital Tornú. Metodología: estudio descriptivo y comparativo, observacional, retrospectivo, transversal, cuantitativo; instrumento: fichas de registro de evaluación y evolución internas de la Residencia. Resultados: la intervención más prevalente fue: uso terapéutico de las actividades y ocupaciones con un 41,04 por ciento en internación y 47 por ciento en reumatología. Entre estos se destacan las métodos preparatorios con un 56,33 por ciento en internación y un 84,7 por ciento en reumatología. Se observó diferencia significativa en la interconsulta con 28.32 por ciento en internación y 5 por ciento en reumatología. Por último, el motivo de alta más frecuente en internación fue alta médica con el 56 por ciento (n:43), seguido de cumplimiento de objetivos con el 16, 4 por ciento (n: 10), y el menos frecuente fue negativa con el 1,6 por ciento (n: 1). En reumatología solo se registraron dos motivos abandono de tratamiento con el 65 por ciento (n: 43) y cumplimiento de objetivos con el 34 por ciento (n: 22). Conclusiones: la intervención que más prevaleció en ambas áreas se debe al gran porcentaje de métodos preparatorios, siendo mayor en reumatología dado que éstos se vinculan con el alivio sintomático. La interconsulta no se realizó con la frecuencia necesaria que requiere la complejidad del paciente agudo, por lo que consideramos relevante plantear estrategias de comunicación con el equipo.

The aim of this study is to know the process of occupational therapy treatment given to rheumatology outpatient, and Clinical and Medical Intensive Care Unit inpatient of Tornú Hospital. Methodology: descriptive, comparative, observational, retrospective, cross-sectional and quantitative instrument; Residence registration evaluation forms and internal evolution. Results: the most prevalent intervention was the therapeutic use of occupations and activities with 41.04 percent in inpatient and 47 percent in outpatients (rheumatology). Among these the preparatory methods are highlighted in both areas with a 56.33 percent in inpatients and 84.7 percent in outpatients (rheumatology). A significant difference was found in interconsultation with a 28.32 percent in inpatients and 5 percent in outpatients (rheumatology). Lastly, the most frequent reason for discharge from occupational therapy treatment in inpatients was clinical discharge with 56 percent (n = 43), followed by goal achievement 4 percent (n = 10), and the least frequent was denial to receive treatment 1, 6 percent (n = 1). Only two reasons were identified in rheumatology: non-compliance with treatment 65 percent (n = 43) and goal achievement with 34 percent (n = 22). Conclusions: the most prevalent intervention in both areas is due to the large percentage of preparatory methods used, being higher in rheumatology since these are associated with symptomatic relief. The interconsultation was not performed with the frequency required by the acute patient´s complexity. According to these results we consider relevant to develop new communication strategies with the team.

Desigualdades socioeconômicas e demográficas como fatores de risco para a artrite autorreferida: estudo de base populacional em adultos no Sul do Brasil / Socioeconomic and demographic inequalities as risk factors for self-reported arthritis: a population-based study in southern Brazil

Estimar a prevalência de artrite ou reumatismo autorreferido e os fatores associados. Realizou-se um estudo transversal de base populacional em Florianópolis, Santa Catarina, Brasil, com 1.720 adultos entre 20 e 59 anos. A presença de artrite ou reumatismo autorreferido foi analisada por meio do modelo hierárquico de determinação no nível demográfico, socioeconômico, comportamental e uso de serviços de saúde. Utilizou-se análise de regressão logística para avaliar a associação entre as variáveis. A prevalência de artrite ou reumatismo autorreferido foi de 7,7% (IC95%: 6,4-8,9). A chance de artrite ou reumatismo autorreferido foi duas vezes maior entre as mulheres, maior entre aqueles com índice de massa corporal (IMC) > 30kg/m²,diretamente proporcional à idade e inversamente proporcional à escolaridade. A prevalência de artrite ou reumatismo autorreferido foi maior do que a estimativa nacional no ano de 2008. Essa realidade sugere a necessidade de um planejamento de políticas públicas voltado para esse agravo de saúde.

The study aimed to estimate prevalence of self-reported arthritis or rheumatism and associated factors. This was a cross-sectional population-based study in Florianopolis, Santa Catarina State, Brazil, with 1,720 adults ranging from 20 to 59 years of age. Presence of self-reported arthritis or rheumatism was analyzed with a hierarchical approach, considering demographic, socioeconomic, and behavioral variables and use of health services. Logistic regression was used to evaluate the association between the outcome and independent variables. Prevalence of self-reported arthritis or rheumatism was 7.7% (95%CI: 6.4-8.9). The odds of self-reported arthritis were twice as high in women, and increased self-reported arthritis was directly associated with BMI > 30kg/m² and increasing age and inversely proportional to schooling. Self-reported arthritis or rheumatism was higher in this sample than in Brazilian adults in general in 2008. The results suggest the need to plan public health policies to address this problem.