RESUMEN
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment. A 5-year-old girl was diagnosed preB cell Acute Lymphoblastic Leukemia (ALL). She received chemotherapy according to the previously described modified St. Jude total therapy studies XIII. Five days after the fourth dose of vincristine, she presented with bilateral ptosis. Neurological examination revealed bilateral ptosis, and complete external opthalmoplegia with normal pupillary and corneal reflexes. She received 3.8 mg cumulative dose of vincristin before development of ptosis. A neuroprotective and neuroregenerative treatment attempt with pyridoxine and pyridostigmine was initiated. The bilateral ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks. The both agents were given for 3 weeks and were well tolerated without any side effects. During the follow up period we did not observe residue or recurrence of the ptosis.
Asunto(s)
Antineoplásicos Fitogénicos/efectos adversos , Blefaroptosis/inducido químicamente , Preescolar , Inhibidores de la Colinesterasa/uso terapéutico , Enfermedades de los Nervios Craneales/inducido químicamente , Femenino , Humanos , Oftalmoplejía/inducido químicamente , Polineuropatías/inducido químicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Bromuro de Piridostigmina/uso terapéutico , Piridoxina/uso terapéutico , Vincristina/efectos adversos , Complejo Vitamínico B/uso terapéuticoAsunto(s)
Adulto , Gluconato de Sodio Antimonio/administración & dosificación , Enfermedades de los Nervios Craneales/inducido químicamente , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Nervio Glosofaríngeo/efectos de los fármacos , Humanos , Inyecciones Intramusculares , Lesión Renal Aguda/inducido químicamente , Leishmaniasis Visceral/tratamiento farmacológico , Masculino , Parálisis/inducido químicamente , Nervio Vago/efectos de los fármacosRESUMEN
Very few cases of the "intermediate neurotoxic syndrome", a type of neurotoxic effect or organophosphate compound have been reported in the literature. We are reporting a case that developed the clinical features of such type of neurotoxic effect after 55 hours of taking the organophosphorus compound.