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2.
Iranian Journal of Pediatrics. 2009; 19 (1): 69-74
en Inglés | IMEMR | ID: emr-91421

RESUMEN

Reversible posterior leukoencephalopathy syndrome [RPLE] is an increasingly recognized disorder, most commonly associated with immunosuppressive and cytotoxic agent, malignant hypertension and toxemia of pregnancy. Neurological symptoms are headache, mental and visual disturbance, and seizures. Brain MRI findings are symmetrical bilateral hyper intense areas of occipital and parietal lobes in T2-weighted magnetic resonance [MR] images. This finding is reversible with prompt successful treatment which may take days to weeks for full reversal. We observed a case of status epilepticus which occurred 32 days after liver transplantation in a patient on regimen consisting of Tacrolimus [FK 506]. He had no history of neurologic disease or metabolic abnormalities. Typical findings of RPLE were present on brain MRI. The recurrence of seizures terminated after a few hours with adding Na-valproate to Phenytoin, Phenobarbital and Midazolam. The radiological finding of brain MRI gradually diminished after several weeks. A physician should be alert of seizures during early post transplant period of liver transplantation. He should bear in mind the diagnosis of RPLE and consider discontinuation of immunosuppressive drugs


Asunto(s)
Humanos , Masculino , Síndrome de Leucoencefalopatía Posterior/etiología , Síndrome de Leucoencefalopatía Posterior/complicaciones , Síndrome de Leucoencefalopatía Posterior/diagnóstico por imagen , Estado Epiléptico/tratamiento farmacológico , Estado Epiléptico/etiología , Estado Epiléptico/diagnóstico por imagen , Trasplante de Hígado/efectos adversos , Inmunosupresores/efectos adversos , Inmunosupresores , Imagen por Resonancia Magnética/estadística & datos numéricos , Tacrolimus/efectos adversos , Tacrolimus , Ácido Valproico , Midazolam , Fenitoína , Fenobarbital
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