Guinea pig maximization test for trichloroethylene and its metabolites / 生物医学与环境科学（英文）

<p><b>OBJECTIVES</b>To study the contact allergenic activities of trichloroethylene (TCE) and its three metabolites trichloroacetic acid, trichloroethanol and chloral hydrate.</p><p><b>METHODS</b>A modified guinea pig maximization test (GPMT) was adopted. The skin sensitization (edema and erythema) was observed in trichloroethylene, trichloroacetic acid, trichloroethanol, chloral hydrate and 2,4-dinitrochlorobenzene.</p><p><b>RESULTS</b>The allergenic rate of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 71.4%, 58.3% and 100.0% respectively, and that of trichloroethanol and chloral hydrate was 0%. The mean response score of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 2.3, 1.1, 6.0 respectively. The histopathological analysis also showed an induction of allergenic transformation in guinea pig skin by both TCE and trichloroacetic acid.</p><p><b>CONCLUSION</b>TCE appears to be a strong allergen while trichloroacetic acid a moderate one. On the other hand, both trichloroethanol and chloral hydrate are weak sensitization potentials. Immunologic reaction induced by TCE might be postulated as the pathological process of this illness. Consequently, it is suggested that in the mechanism of Occupational Dermatitis Medicamentose-Like (ODML) induced by TCE, the chemical itself might be the main cause of allergy. As one of its metabolic products, trichloroacetic acid might be a subordinate factor.</p>

Níveis residuais de óxido de etileno etilenocloridrina e etilenoglicol em sondas endotraqueais de borracha, em diferentes tipos de embalagens / Levels of ethylene oxide ethylene cloridrin and ethylene glycol residue in endotracheal tubes of rubber in different types packaging

A análise dos teores residuais verificada em sondas endotraqueais de diversos diâmetros internos, em funçäo dos tipos de embalagens utilizados, nas diversas posiçöes na câmara de esterilizaçäo, revelou baixos teores residuais de óxido de etileno, em embalagem de papel grau cirúrgico verso polipropileno. Altos teores foram verificados em embalagens de filme de poliamida com poliamida. Näo foram detectados teores significativos de etilenocloridrina e etilenoglicol