RESUMEN
As modificaçöes do ritmo sono-vigília, quando ocorrem na atividade aeroespacial, afetam o relógio biológico e a dessincronizaçäo tem origem principalmente no marcador da percepçäo da noite e do dia. Assim, o uso de soníferos torna-se importante pelos riscos da açäo residual e conseqüente embotamento cognitivo. Os medicamentos ansiolíticos de uso täo comum, dada a facilidade com que säo receitados, devem figurar entre os produtos cujos efeitos adversos säo desprezados, pois o alívio da angústia ganha prioridade. Finalmente os fármacos antidepressivos, em virtude da multiplicidade de estruturas químicas e mecanismos de açäo, envolvem efeitos iatrogênicos variados e perigosos para a atividade em questäo. Seguem-se recomendaçöes saneadoras.
Asunto(s)
Humanos , Fármacos del Sistema Nervioso Autónomo/farmacología , Ansiolíticos/farmacología , Antidepresivos/farmacología , Astronautas , Aviación , Hipnóticos y Sedantes/farmacología , Sueño/efectos de los fármacos , Vigilia/efectos de los fármacosRESUMEN
Rats exposed to lead (lead acetate) in doses of 0.2 and 0.5 mg/ml in drinking water for a period of 90 days showed mild to moderate changes in food consumption compared to control group. Drug interactions in lead exposed rats with metoclopramide, atropine sulphate, propranolol, cyproheptadine and mepyramine maleate when administered intraperitoneally caused -30 to +30 percentage variation in food intake indicating the influence of adrenergic, serotonergic and cholinergic neurotransmitters with no change in mean body weight of lead treated rats.
Asunto(s)
Administración Oral , Animales , Anorexia/inducido químicamente , Fármacos del Sistema Nervioso Autónomo/farmacología , Peso Corporal/efectos de los fármacos , Encéfalo/efectos de los fármacos , Interacciones Farmacológicas , Conducta Alimentaria/efectos de los fármacos , Masculino , Compuestos Organometálicos/administración & dosificación , RatasRESUMEN
The effects of neuropharmacological agents on the motility of irradiated and non-irradiated Angiostrongylus cantonensis adult females were studied. GABA induced complete paralysis in non-irradiated and 5,000 R-irradiated worms, but caused only slight paralysis on 10,000 R-irradiated worms. The paralytic effect of GABA was antagonised by picrotoxin. The reason for low susceptibility of heavily irradiated worms to GABA is not known. There was no difference in susceptibility of non-irradiated and irradiated worms to other neuropharmacological agents including eserine, phenylephrine and dibenamine.
Asunto(s)
Angiostrongylus/efectos de los fármacos , Animales , Fármacos del Sistema Nervioso Autónomo/farmacología , Convulsivantes/farmacología , Dibencilcloretamina/farmacología , Femenino , Rayos gamma , Larva/efectos de la radiación , Masculino , Metastrongyloidea/efectos de la radiación , Movimiento/efectos de los fármacos , Fenilefrina/farmacología , Fisostigmina/análogos & derivados , Picrotoxina/farmacología , Ratas , Ratas Endogámicas , Estricnina/farmacología , Ácido gamma-Aminobutírico/farmacologíaAsunto(s)
Animales , Antibacterianos/farmacología , Fármacos del Sistema Nervioso Autónomo/farmacología , Temperatura Corporal/efectos de los fármacos , Frío , Depresión Química , Inducción Enzimática/efectos de los fármacos , Hígado/enzimología , Masculino , Ratas , Triptófano Oxigenasa/biosíntesisRESUMEN
A method for continuous registration of perfusion rate of frog blood vessels has been developed utilizing a modified Marey's tambour with lever system, connected to the perfusion bottle. The responses of frong blood vessels to some autonomic drugs have been studied using this method.