Single Family Members with Multiple Impacted teeth: A Rare Case Report.

Multiple impacted teeth of idiopathic origin are a rare dental anomaly. Various local and systemic causative factors have been implicated in the literature; however, it is unknown at present about the localization of the genetic defect in the phenotype of failure of eruption. Retained primary teeth is a well-known process, but multiple permanent and supernumerary teeth that too asymptomatic is surely a rare possibility. This article aims in to consolidate and organize the available information regarding the tooth eruption failure and to collaborate the current evidence with the report of three adult sibling’s cases of failure of eruption of multiple permanent teeth in a family without a known cause.

Clinical profile and mutation analysis of xeroderma pigmentosum in Indian patients.

Background: Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder characterized by cutaneous and ocular photosensitivity and an increased risk of developing cutaneous neoplasms. Progressive neurological abnormalities develop in a quarter of XP patients. Aim: To study the clinical profile and perform a mutation analysis in Indian patients with xeroderma pigmentosum. Methods: Ten families with 13 patients with XP were referred to our clinic over 2 years. The genes XPA, XPB and XPC were sequentially analyzed till a pathogenic mutation was identified. Results: Homozygous mutations in the XPA gene were seen in patients with moderate to severe mental retardation (6/10 families) but not in those without neurological features. Two unrelated families with a common family name and belonging to the same community from Maharashtra were found to have an identical mutation in the XPA gene, namely c.335_338delTTATinsCATAAGAAA (p.F112SfsX2). Testing of the XPC gene in two families with four affected children led to the identification of the novel mutations c.1243C>T or p.R415X and c.1677C>A or p.Y559X. In two families, mutations could not be identified in XPA, XPB and XPC genes. Limitation: The sample size is small. Conclusion: Indian patients who have neurological abnormalities associated with XP should be screened for mutations in the XPA gene.