RESUMEN
Abstract This communication reports the second known case of oral phaeohyphomycosis in a patient with squamocellular carcinoma of the lip. The patient, an 82-year-old black woman, a former smoker (for more than 30 years), suffering from an ulcerous vegetative lesion in the middle third of the lower lip for approximately 12 months. The result of the histopathological analysis indicated carcinoma, with well-differentiated keratinized squamous cells and the presence of septate mycelial filaments. In the direct mycological examination, thick and dematiaceous septate mycelial filaments were observed. After the resection surgery, the patient did not need to use an antifungal drug to treat the phaeohyphomycosis, and no follow-up radiotherapy was needed to treat the squamocellular carcinoma. We stress that the presence of the squamocellular lesion of the lip was a possible contributing factor to the infection.
Asunto(s)
Humanos , Femenino , Anciano de 80 o más Años , Neoplasias de los Labios/complicaciones , Carcinoma de Células Escamosas/complicaciones , Feohifomicosis/diagnóstico , Feohifomicosis/patología , Labio/patología , Brasil , Neoplasias de los Labios/cirugía , Carcinoma de Células Escamosas/cirugía , Técnicas Microbiológicas , Resultado del Tratamiento , Feohifomicosis/cirugía , Histocitoquímica , Labio/cirugía , MicroscopíaRESUMEN
Abstract Phaeohyphomycosis is an infection caused by a filamentous fungus that contains pigment melanin in its cell wall. We report two cases caused by Exophiala sp. emphasizing the clinical variability of the disease, as well as diagnostic and therapeutic difficulties of this opportunistic infection in immunosuppressed patients (kidney transplant).
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Exophiala/aislamiento & purificación , Trasplante de Riñón/efectos adversos , Feohifomicosis/patología , Antifúngicos/uso terapéutico , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Infecciones Oportunistas/inmunología , Infecciones Oportunistas/patología , Infecciones Oportunistas/terapia , Feohifomicosis/inmunología , Feohifomicosis/terapia , Piel/patologíaRESUMEN
Phaeohyphomycosis is a disease caused by dematiaceous fungi with a worldwide geographic distribution and broad spectrum. It is most commonly found in adult individuals of both genders and all races. We report the case of a 57-year-old woman with phaeohyphomycosis in the ungual apparatus.
Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Enfermedades de la Uña/microbiología , Feohifomicosis/microbiología , Piel/microbiología , Antifúngicos/uso terapéutico , Enfermedades de la Uña/tratamiento farmacológico , Enfermedades de la Uña/patología , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/patología , Piel/patología , Resultado del TratamientoRESUMEN
Subcutaneous phaeohyphomycosis is an infection caused by dematiaceous fungi which mainly affects immunosuppressed patients. We report a case of subcutaneous phaeohyphomycosis on the back of the left hand in a kidney transplant patient who had been taking prednisone, tacrolimus, and azathioprine daily for 3 years.
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Feohifomicosis/patología , Dermatosis de la Mano/patología , Biopsia , Terapia de Inmunosupresión/efectos adversos , Trasplante de Riñón , Huésped Inmunocomprometido , Feohifomicosis/cirugía , Dermatosis de la Mano/cirugíaRESUMEN
The goal of this study was to review 18 cases of phaeohyphomycosis in Rio Grande do Sul. The records of all of the patients with a diagnosis of phaeohyphomycosis between 1995-2010 were reviewed. Twelve of the 18 patients (66.6%) were male. The average age of the patients was 50 years old (range: 16-74 years). Eleven patients (61%) presented with subcutaneous lesions. Seven patients (38.8%) had received a solid organ transplant. In all of the cases, the presence of melanin in the fungal cells was determined by Fontana-Masson staining of tissue sections and documented. Among the 18 patients, a total of 11 different fungal species were isolated. The causative organisms included Exophiala jeanselmei, Alternaria, Curvularia, Cladophialophora and Colletotrichum gloeosporioides. To our knowledge, this review reports the first case of subcutaneous phaeohyphomycosis caused by C. gloeosporioides in a lung transplant patient. The number of reported cases of phaeohyphomycosis has increased in the last decade. In a number of cases, this increased incidence may be primarily attributed to iatrogenic immunodeficiency.