Eccrine syringofibroadenomatosis of the reactive subtype occurring in chronic poorly-controlled psoriasis.

Eccrine syringofibroadenomatosis (ESFA) is a rare adnexal tumor with acrosyringeal differentiation. Clinically, it can be mistaken for granulomatous infections or malignancies such as squamous cell carcinoma. Despite the rarity of the condition, we recently encountered two cases of the reactive subtype, which occurred in patients with poorly controlled chronic psoriasis. Both patients presented with long‑standing, thick verrucous lesions on the lower legs. The diagnosis was made after histological examination and exclusion of infectious and neoplastic disorders. As this is a reactive disorder, management is focused on treating the underlying condition. Unfortunately, psoriasis was difficult to manage in both our patients and they defaulted further treatment. It is important to recognize ESFA as it can be confused with infectious or malignant disorders.

Histopathological Study of Neoplastic Lesions of Breast.

Aims and Objectives: 1) To study the incidence of various neoplastic lesions of breast. 2) To study the histopathological features of neoplasms and classify them according to WHO classification (2003). 3) To compare the results of study with those of other studies. Materials and Methods: The present study was prospective as well as retrospective which include 252 cases from October 2005 to October 2010. The specimens were received in different forms such as excisional biopsies, modified radical mastectomies, simple mastectomies, tru-cut biopsies, wide local excision and quadrantectomy specimens. Detail gross examination was done for each specimen and histopathological features were studied to classify neoplasms according to WHO classification 2003. Results: Out of total 9086 biopsies, breast biopsies were 366 (4%) during this 5 year study. Total 252 breast neoplasms were studied, where, the incidence of benign neoplasms was 50.4% (127 cases) & for malignant neoplasms was 49.6% (125 cases). Among all types of specimen received, excision biopsy was most common (48%). Upper outer quadrant was most commonly involved region for breast neoplasms. Fibroadenoma, benign phyllodes neoplasm, tubular adenoma, central papilloma, peripheral papilloma, lipoma and neurofibroma were seen among benign neoplasms. While invasive ductal carcinoma not otherwise specified, mixed carcinoma, metaplastic carcinoma, mucinous carcinoma, malignant phyllodes neoplasm, invasive lobular carcinoma, invasive papillary carcinoma, medullary carcinoma, intracystic papillary carcinoma, malignant peripheral nerve sheath neoplasm and collision neoplasm were studied among malignant neoplasms. The most common benign neoplasm was fibroadenoma (87%) and invasive ductal carcinoma not otherwise specified (88%) was malignant neoplasm. Conclusions: Fibroadenoma was the most common (87%) benign breast neoplasm. Among all malignant breast neoplasms, invasive ductal carcinoma, not otherwise specified was most common (88%). In cases of benign neoplasms, the highest incidence was found in the age group of 10-20 years (37%) while in the malignant neoplasms, it was 40 - 60 years (51.2%). The incidence of malignant breast neoplasm in male was 2.4%.

Breast diseases in Southern Yemen

To investigate the magnitude of breast diseases, and its frequency distribution in different age groups in Hadramout, Yemen. This is a prospective study conducted at the Central Laboratory of Ibn-Sinna Hospital Hadramout, Yemen from January 2006 to December 2009. Patients attending surgical units for breast problems were eligible. Patients were assessed clinically and referred to the laboratory center to confirm the diagnosis by histopathology. The data were collected from the patients and referral sheets. A total of 635 cases of breast disease were diagnosed. This includes 604 female and 31 male patients. Benign breast diseases [BED] was the most common lesion found in this study comprising 493 cases [77.6%], and 142 [22.4%] comprised malignant cases. Among BBD, the most common lesion was fibroadenoma [40.5%] followed by fibrocystic changes [16%], other benign breast lesions [10%], and inflammatory lesion [8%]. The age groups affected by BBD were: 20-29 years for fibroadenoma; 30-39 years for fibrocystic change; 20-29 years for other benign breast lesions; and 30-39 for inflammatory lesions, and carcinoma of the breast was common in the 40-49 age group. The left breast was affected in 331 [52%] cases, the right in 283 [45%], while in 3%, both breasts were affected. Fibroadenoma was the most frequently diagnosed benign breast lesion in Hadramout. An educational program is needed to alert patients of the significance of breast masses

Breast diseases; spectrum in Wah Cantt; POF hospital experience

To find out the magnitude of breast diseases and their distribution in different age groups among the patients attending surgical OPD for surgical consultation at POF Hospital Wah Cantt. This is a retrospective observational type of study. Patients attending surgical OPD for breast problem from January 2000 to December 2007 were included. They were assessed clinically and their diagnosis was confirmed by cytological [FNAC] or histopathological [biopsy] examination. Records were taken from pathology and surgery department and the patients were retrospectively reviewed. 954 cases of breast disease were diagnosed. These include 905 female and 49 male patients. Benign breast diseases [BBD] were the most common lesions of the breast found in this study [71.5%] whereas malignant lesions were on the rise with each passing year [28.5%]. Among BBD, the most common lesion was fibroadenoma [49%] followed by breast abscess [13%], Fibrocystic disease [9.3%] and gynecomastia [6.8%]. 271 cases [28.5%] were malignant lesions. This includes 269 female and 2 male cases. The common ages for BBD were, 12-30 years for fibroadenoma, 15-40 years for breast abscess, 18-40 years for fibrocystic disease and 15-29, 50-59 for gynecomastia respectively, whereas carcinoma breast was seen in the age group of fifties initially, getting more common in forties, in the later part of study. We conclude from this study that BBD is the most frequent breast ailment. Among the BBD, fibroadenoma was the most common lesion. Breast carcinoma cases were becoming more frequent but reached hospital at a late stage of the disease. Infiltrating ductal carcinoma was the most common malignancy noted

Spectrum of benign breast diseases in females presenting with breast lump

To find out the frequency of benign breast diseases in female patients. This study included. 70 female patients presenting with breast lump. These patients were clinically evaluated with special focus breast lump and axilla to exclude the malignancy. These patients with the obvious clinical feature of malignancy or diagnosed of case of malignant pathology were excluded from the study. In these patients FNAC [Fine Needle Aspiration Cytology] were performed to confirm the diagnosis. Excisional Biopsy was done in non-conclusive FNAC. History of the patients, finding of breast lump, result of FNAC or excisional biopsy were registered in prepared Performa. In this study we found Fibroadinoma in 29 [41%] patients followed by Fibrocystic Disease in 20 [29%] patients. Breast abscess was found in 8 [11%]. The other benign breast diseases were Duct Papiloma, Cyst, Granulomatous Mastitis in 7 [10%], 5 [7%] and 1 [1%] patients respectively. Among the benign breast diseases Fibroadinoma is the most common disease and Fibrocystic Disease is the next common disease. Other benign breast diseases were also breast abscess Cyst, Duct Papiloma and Granulomatous Disease

Clinicopathologic features of breast disease in Jamaica: findings of the Jamaican Breast Disease Study, 2000-2002 / Características clínico-patológicas de la enfermedad de mamas en Jamaica: hallazgos del estudio jamaicano de la enfermedad de mamas, 2000-2002

OBJECTIVE: To describe the clinicopathologic profile of breast disease in Jamaica. METHODS: The Jamaican Breast Disease Study is an ongoing prospective, multidisciplinary investigation of breast disease at the University Hospital of the West Indies (UHWI). The initial phase was a prevalence survey comprising all consenting patients referred to the Surgical Outpatient Department (SOPD) UHWI, for breast disease. Demographic, clinical, radiologic and pathologic information were recorded for each patient and the data for the first three years (2000-2002) were analyzed. RESULTS: A total of 1189 patients was enrolled for the study period (28.8% of all new SOPD patients). The age range was10 to 93 years (mean/SD = 36.5 +/- 16.4 years) with a female : male ratio of 14:1. Most patients (67.8%) presented with a palpable lump and the clinical diagnosis was benign in the majority (70.4%) of patients. Fibroadenoma was the most common benign histologic result (39.4% of all biopsies) followed by non-proliferative (fibrocystic) disease (19.3% of all biopsies). Proliferative disease without atypia, complex fibroadenoma and atypical ductal hyperplasia accounted for 6.9%, 2.6% and 0.4% of biopsies respectively. Overall, 23.4% of biopsies showed malignant histology (10.8% patients); invasive ductal carcinoma accounted for the majority of these cases (69.5%). CONCLUSIONS: The majority of patients with breast disease in Jamaica are young women with clinically benign disease. There was a low prevalence of clinically significant premalignant disease. This is the first study to prospectively describe the clinicopathologic features of breast disease in Jamaica and supports the need for advocating breast cancer screening to facilitate detection of significant premalignant disease and early stages of breast cancer.

OBJETIVO: Describir el perfil clínico-patológico de la enfermedad de mamas en Jamaica. MÉTODOS: El "Estudio jamaicano de la enfermedad de mamas" - que continua realizándose en la actualidad en el Hospital Universitario de West Indies (HUWI) - consiste en una investigación prospectiva y multidisciplinaria de la enfermedad de mamas. La fase inicial fue un estudio de prevalencia que abarcó a todos los pacientes que dieron su consentimiento, y que fueron remitidos al Departamento de Cirugía Ambulatoria (DCA) de HUWI a causa de la enfermedad de mamas. Se registró información demográfica, clínica, radiológica y patológica de cada paciente, así como los datos referidos a los primeros tres años (2000-2002). RESULTADOS: Un total de 1189 pacientes fueron captados para el periodo de estudio (28.8% de todos los pacientes nuevos del DCA). El rango de edad fue de 10 a 93 años (media/SD = 36.5 + / - 16.4 años) con una proporción hembra:varón de 14:1. La mayoría de los pacientes (67.8%) presentó un nódulo palpable y el diagnóstico clínico fue benigno en la mayoría (70.4%) de los pacientes. El fibroadenoma fue el resultado histológico benigno más común (39.4% de todas las biopsias) seguido por la enfermedad (fibrocística) no proliferativa (19.3% de todas las biopsias). La enfermedad proliferativa sin atipia, el fibroadenoma complejo y la hiperplasia ductal atípica representaron el 6.9%, 2.6% y 0.4% de las biopsias respectivamente. En general, el 23.4% de las biopsias mostraron histología maligna (10.8% de los pacientes); el carcinoma ductal invasivo representó la mayoría de estos casos (69.5%). CONCLUSIONES: La mayor parte de los pacientes con la enfermedad de mamas en Jamaica son mujeres jóvenes con enfermedades clínicamente benignas. Hubo una baja prevalencia de enfermedades premalignas clínicamente significativas. Este es el primer estudio dirigido a describir prospectivamente las características clínico-patológicas de la enfermedad de mamas en Jamaica, y respalda la necesidad de abogar por el pesquisaje del cáncer de mamas, a fin de facilitar la detección de enfermedades premalignas significativas y las fases tempranas del cáncer de mamas.

Patologia benigna da mama / Mammary benign patology

A patologia benigna da mama é responsável por cerca de 80% das massas palpáveis. Seu diagnóstico diferencial é amplo, envolvendo distúrbios no desenvolvimento, doenças inflamatórias, alterações fobrocísticas, tumores benignos e doença mamária proliferativa, entre outros. O fibroadenoma, tumor benigno da mama, é a neoplasia mamária mais comum em pacientes menores de 35 anos, já os cistos são mais freqüentes na perimenopausa. O diagnóstico diferencial entre nódulos sólidos ou císticos poderá ser feito por meio da punção aspirativa com agulha fina ou pela ultra-sonografia. Nos nódulos císticos a punção por agulha fina além de diagnóstica, é conduta terapêutica. Neste artigo serão revisados aspectos dos diagnósticos diferenciados entre estes tumores, as abordagens terapêuticas e a associação entre tais patologias e câncer de mama.

audit of 149 consecutive breast biopsies in Ibadan, Nigeria

To study the outcomes of one hundred and forty nine consecutive breast biopsies in both male and female patients in one arm of the general surgery division of the department of surgery, university college hospital Ibadan. A retrospective study of the case files and histopathology reports of 149 patients who had biopsies of the breast from May 1996 to September 2004. The study showed that below the age of 30 years, there was no malignancy detected in 85 breast biopsies, however as the age increased it was seen that less than one out of four biopsies were malignant when the patients were aged between 31 and 40 years, rising to one out of four biopsies for the 41-50 and 51-60 age-groups. The 61-70 yielded roughly one out of three whilst two out of three breast biopsies were malignant in the 71-80 age-groups. Majority of breast lumps are benign and women have a probability of one chance in 10 that their biopsies may be malignant. However under 30 years this is unlikely. Above the age of 40 years the chance of malignancy rises to a one in four which will strongly support screening methods for women above 40 years. For record purposes, fibroadenoma is still the most common breast lesion in women under 30 years and invasive ductal carcinoma is the most common histopathological type of breast cancer in Ibadan, Nigeria

[Evaluation of prevalence and risk factors of asymptomatic masses of breast in women visiting in khanevadeh hospital [Oct 2005-2006]]

Mammary disorders are among the most important elements causing women to present to a physician. Mammary disorders can Vary form benign masses to malignant cancerous tumors. The occurrence and the elements contributing to the occurrence of asymptomatic breast tumors in the women having presented to Army staff's family Hospital within the term from Oct 2005-2006. This is a descriptive- analytical study carried out on 660 subjects. The subjects were sleeted at random from among the mummer presenting. To the clinic for reasons other than mammary disorders. They were subjected to full breast examinations. Questionnaires were distributed among the subjects in order to survey the elements contributing to the occurrence of breast tumors and the results from the completed questionnaires were analyzed. 5 numbers of total 660 patients were examined in this research had breast tumors and only one case had malignant mass.20% of them malignant 20% cyst and 60% were fibroadenoma. frequency of asymptomatic breast tumors in this study are [0/7%] and 80% of them is benign where as 20% of asymptomatic breast mass was malignant therefore self examination and examination by physician periodically, specially in high risk patient is important

Frequency of benign breast diseases in female patients presenting with breast lumps - a study at sir Ganga Ram Hospital, Lahore

To determine the frequency of benign breast diseases in female patients in our setup. Prospective descriptive study. The study was carried on female patients presenting at surgical out door of Sir Ganga Ram Hospital, Lahore during one year i.e. January 2001 to January 2002. Two hundred female patients presenting with breast lumps at surgical out door of Sir Ganga Ram Hospital, Lahore during one year were studied. All the patients were examined clinically with special emphasis on breast, axilla and supra clavicular fossae. Basic laboratory investigations including blood complete examination, urine complete examination and chest X -ray were done for all the patients. Breast imaging and FNAC of lumps were also done. Final diagnosis was based upon histological examination of the tissues biopsied from the lump. After collecting data, written in proforma, window SPSS software was used to analyze the results. This study shows a high f requency of fibroadenoma [45%] in Pakistani females. Fibrocystic disease is second in frequency and accounts for 36% patients.8% patients had intraductal papilloma and three percent suffered from duct ectasia.5% patients had other conditions related to breast including two patients presenting with pre histological diagnosis of fibrocystic disease who turned out to be malignant after histopathology. Most of the patients had age range of 20-29 years. Fibroadenoma is the commonest of all benign breast diseases in Pakistani women. Fibrocystic change is the second in this regard. Benign lesions of the breast can resemble its carcinoma on clinical examination

Benign breast lesions in prepubertal female children--a study of 20 years.

A clinicopathological study of benign breast lesions in prepubertal female children was done retrospectively for 20 years. Thirty-seven cases of benign breast lesions like fibroadenoma in 22 (59.5%) cases, juvenile fibroadenoma in 9 (24.2%) cases, virginal hypertrophy in 3 (8.1 %) cases, cystosarcoma phylloides, duct papilloma and tuberculosis of the breast in one (2.7%) case each were seen. The majority of the cases of breast lesions were from urban area ie, 34 (91 .9%) cases. The commonest age of occurrence of benign breast lesion was observed between 7.5 and 11.5 years. In 2 (5.4%) cases bilateral virginal hypertrophy was seen. The aim of presenting this paper is to study the occurrence of breast lesions in prepubertal age especially before menarche. In rare case even the possibility of malignancy has to be ruled out.

Patologias benignas da mama / Benign breast diseases

As duas lesões benignas predominantes na literatura são os fibroadenomas e as alterações fibrocísticas. O objetivo deste estudo foi estimar a prevalência destes tumores na área de abrangência do Intituto de Patologia, em Passo Fundo e regiões vizinhas, considerando localização, idade e frequência em uma análise dos últimos 10 anos. Os autores concluem que as doenças benignas da mama merecem atenção especial por sua alta prevallência, seu impacto na qualidade de vida do paciente e, para alguns tipos histológicos, seu potencial de malignização. Além disso, o diagnóstico clínico, radiológico e ecográfico desses tumores pode simular uma neoplasia maligna de mama

Spectrum of breast disease in young females: a retrospective study of 1315 patients.

A total of 1315 breast lesions seen in women up to 40 years of age were registered in the files of Pathology Department. Out of these 807 were benign and 508 malignant lesions. Breast carcinoma was very rare up to second decade of life but its incidence progressively increased with age. Among benign tumours fibroadenomas were the commonest tumours. This study shows a higher incidence of inflammatory diseases and malignant tumours in young females as compared to the reports from the West.

Factores de riesgo y su correlación con algunos mercadores tumorales en la incidencia de cáncer mamario en pacientes pre y postmenopáusicas / Risk factors and its correlation with some tumoral markers in breast cancer incidence in pre and postmenopausic patients

Entre enero y noviembre de 1992, 48 mujeres con desórdenes benignos de la mama, se estudiaron y compararon con 152 pacientes con enfermedad maligna. Se midió el contenido de Fosfatasa alcalina (FAC) en el suero de estas pacientes premenopáusicas y postmenopáusicas. A todas ellas se los realizó historia clínica que incluyó peso, talla e índice de masa corporal (IMC) (peso/talla²). Las pacientes se agruparon de acuerdo al tipo de lesión mamaria, encontrándose que la FAC presentaba valores frecuentemente más altos en pacientes con enfermedad maligna, que en aquéllas con desórdenes benignos. El estado biológico de esta enzima, relata probablemente la actividad en estos tejidos a través de fibroadenoma hasta adenocarcinoma, en donde presenta mayor actividad. Los valores de FAC (= 90 UI/L), IMC, estado menstrual y tipo histológico, se compararon, encontrándose una correlación significativa entre estos parámetros

Análisis exploratorio de algunas características epidemiológicas del tumor phyllodes, Hospital Edgardo Rebagliati Martins Perú (1989-1995) / Phyllodes tumor: an exploratory study of some epidemiologic features Hospital Edgardo Rebagliati Martins (1989-1995)

El tumor Phyllodes (Fibroadenoma Intracanalicular Gigante) es un tipo de tumor de mama que presenta en los últimos años un incremento en su incidencia en algunos países planteando diversas interrogantes epidemiológicas. El objetivo del siguiente estudio es realizar un análisis exploratorio de las características epidemiológicas de este tumor basándonos en 53 casos presentados en el Hospital IPSS Edgardo Rebagliati Martins en el período 1989-1995. Dentro de las características más relevantes se encontró un promedio de edad de 43.45 años. Asimismo se observó que el 67.9 por ciento de los casos se presentaron en pacientes premenopáusicas. Dentro de las características ocupacionales se halló una mayor frecuencia en empleadas, en especial profesoras (24.5 por ciento). El 39.6 por ciento de las pacientes eran naturales de Lima y el 69.8 por ciento de ellas residían en la ciudad al momento del diagnóstico. Respecto a los tipos histológicos, predominan las formas benignas con un 81.13 por ciento. El tipo histológico maligno es el menos frecuente y se presenta en mayores de 30 años de edad. En términos generales los hallazgos revelan que el Tumor Phyllodes se presenta en la etapa reproductiva de la mujer. Los hallazgos revelan que cuanto mayor es el número de gestaciones el tumor es poco frecuente. Asimismo no se encuentran evidencias de exposición industrial o de labores de alta exposición a agentes cancerígenos. Un hallazgo que concideramos relevante, es que el cambio de residencia (migración a Lima) estuvo asociado a una menor edad de la paciente al momento de presentación del tumor, lo que plantea un indicio de aparición del tumor con una exposición al ecosistema urbano. Los hallazgos hacen presumir que diversos factores gineco-obstétricos relacionados con la etapa reproductiva juegan un papel importante en la programación de este tumor, consideramos sin embargo que el rol de los factores ambientales amerita mayores investigaciones.

Fibroadenoma de mama: aspectos clínicos e epidemiológicos / Breast fibroadenoma: clinical and epidemiologyc aspects

Os autores revisam 509 prontuários com o diagnóstico clínico de fibroadenoma (FA), do Serviço de Mastologia da Enfermaria 22 da Santa Casa de Misericórdia de Porto Alegre - RS. Foram selecionados para avaliaçäo apenas 385 pacientes já operadas e com correlaçäo clínico-anatomopatológica. Em 372 pacientes ocorreu a confirmaçäo de FA e das quais säo avaliadas a faixa etária, o número e o tamanho dos FA por décadas, a localizaçäo, a correlaçäo de lados e os FA múltiplos. Anotam os patologias associadas e as possíveis complicaçöes cirúrgicas. Concluem que: a - o FA é tumor de mulher jovem, com maior incidência na terceira década; b - o FA é múltiplo em 16 a 20 por cento dos casos e 60 por cento destes seräo bilaterais; c - o FA tem predomínio pelo QSE das mamas; d - o FA quando múltiplo e unilateral é mais freqüênte na mama direita; e - o FA é raro na pós-menopausa; f - o FA e o carcinoma ocasionalmente coincidem, porque säo lesöes freqüêntes