RESUMEN
Accurate and sensitive methods were proposed for the determination of nortriptyline hydrochloride and fluphenazine hydrochloride in mixture. The first method based on first derivative spectrophotometric procedure. Nortriptyline hydrochloride was determined by zero crossing measurements at 255.5 nm. The ordinate value at 262.5 nm was used to calculate the amount of fluphenazine hydrochloride in mixture. An alternative evaluation of both drugs in mixture involved the use of sodium 1,2-naphthoquine-4-sulfonate as a colorimetric reagent for the selective determination of nortriptyline hydrochloride and a fluorimetric method for the determination of fluphenazine hydrochloride alone. The presented methods were successfully applied on laboratory made mixtures and motival tablets. The described methods were compared with official methods for the determination of both drug [1,2]