RESUMEN
The neuroleptic malignant syndrome is an exceedingly rare but potentially fatal condition characterized by parkinsonian type rigidity, rise of temperature and altered consciousness. This idiosyncratic side-effect of almost all psychotic drugs though rare may occur even when neuroleptics are used for a short period. Here a very rare presentation of a case, of neuroleptic malignant syndrome appearing 2 days following 2nd dose of injection fluphenazine decanoate (0.5 ml) IM in whom 1st dose having 30 days prior to the 2nd one did not show any adverse effect, is being reported.
Asunto(s)
Adulto , Relación Dosis-Respuesta a Droga , Flufenazina/efectos adversos , Humanos , Masculino , Síndrome Neuroléptico Maligno/diagnóstico , Esquizofrenia/tratamiento farmacológicoRESUMEN
Two hundred and thirty-two psychiatric Outpatients on depor fluphenazine decanoate for more than six months were examined for Tardive Dyskinesia (TD), using the AIMS rating scale, and the prevalence rates of TD at different criteria of severity were asssessed. The prevalence rates ranged from 7% for patients with asevere TD to 45% for patients with any degree of TD. The sex distribution of patients with TD showed no bias but the female patients were significantly older than the male patients. Increases in prevalence rats of TD were associated with the combination of an anticholinergic anti-Parkinsonian drug with the depot neuroleptic, and with the concomitant use of an oral neuroleptic with the depot preparation. Implications of these finding for the long-term management of schizopherinia are discussed
Asunto(s)
Adulto , Persona de Mediana Edad , Humanos , Masculino , Femenino , Antipsicóticos/efectos adversos , Discinesia Inducida por Medicamentos/etiología , Trastornos Mentales/tratamiento farmacológico , Atención Ambulatoria , Esquizofrenia/tratamiento farmacológico , Anciano de 80 o más Años , Flufenazina/análogos & derivados , Flufenazina/efectos adversos , Preparaciones de Acción RetardadaRESUMEN
A síndrome maligna (SM) é uma reaçäo idiossincrásica e potencialmente fatal ao uso de neurolépticos, caracterizada por febre, rigidez muscular, alteraçöes da consciência e disfunçöes autonômicas. No presente trabalho, apresentamos uma revisäo da literatura sobre a SM nos últimos oito anos, a luz da qual discutimos um possível novo caso que ilustra as dificuldades e a importância de um diagnóstico precoce, condiçäo fundamental para um tratamento efetivo e uma evoluçäo bem-sucedida da SM. Fazemos ainda sugestöes quanto a procedimentos necessários ao pronto diagnóstico, bem como ressaltamos aspectos importantes para futuros estudos