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1.
Artículo en Inglés | IMSEAR | ID: sea-64165

RESUMEN

BACKGROUND: Endogenous or exogenous digoxin can lead to membrane Na+,K+-ATPase inhibition and hypomagnesemia. Low magnesium levels can lead to increased glycosaminoglycans (GAG) concentration in many organs. Aim: To measure the serum levels of pancreatic GAG and glycoproteins, two major components of the extracellular matrix, in patients with chronic calcific pancreatitis (CCP). Serum levels of magnesium and digoxin were also assessed. METHODS: Patients with CCP and age- and sex-matched healthy control subjects (15 each) were studied. Serum GAG, Mg and digoxin levels were measured. RBC membrane Na+,K+-ATPase activity was also assessed. Pancreatic tissue obtained at autopsy from seven patients with CCP and sex- and age-matched healthy subjects who had died in accidents were also tested for GAG and glycoproteins. RESULTS: Total GAG levels were significantly increased in the serum and pancreas of patients with CCP. This was associated with lower serum Mg levels, increased serum digoxin levels and decreased RBC membrane Na+,K+-ATPase activity. CONCLUSION: Exogenous or endogenous digoxin-induced hypomagnesemia and the consequent altered glycoconjugate metabolism may be important in the pathogenesis of CCP.


Asunto(s)
Adulto , Biomarcadores/análisis , Calcinosis/sangre , Estudios de Casos y Controles , Enfermedad Crónica , Digoxina/sangre , Femenino , Glicoconjugados/sangre , Humanos , Magnesio/sangre , Masculino , Pancreatitis/sangre , Probabilidad , Valores de Referencia , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , ATPasa Intercambiadora de Sodio-Potasio/metabolismo
2.
Indian J Physiol Pharmacol ; 1998 Jan; 42(1): 123-6
Artículo en Inglés | IMSEAR | ID: sea-106675

RESUMEN

The present study has examined the glycoconjugate profile in plasma and erythrocyte membranes of 24 adult male gastric cancer patients and an equal number of age and sex-matched controls. Protein-bound hexose, hexosamine and sialic acid were significantly increased in plasma and erythrocytes of gastric cancer patients compared to controls. Elevation of glycoconjugates in circulation is suggested to be a result of increased shedding by the tumor cells or increased synthesis by liver, due to acute phase response.


Asunto(s)
Adenocarcinoma/sangre , Adulto , Proteínas Sanguíneas/metabolismo , Membrana Eritrocítica/metabolismo , Eritrocitos/metabolismo , Glicoconjugados/sangre , Humanos , Masculino , Persona de Mediana Edad , Unión Proteica , Ácidos Siálicos/sangre , Neoplasias Gástricas/sangre
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