RESUMEN
The efficiency and viability of a hemoglobinopathy program was investigated. The program was offered on a voluntary basis to a Brazilian community (Araras, SP) and started with the blood analyses of pregnant women. A total of 2209 pregnant women were screened in the first 39 months and 80 heterozygotes were diagnosed (52 AS, 19 AT and 9 AC). Another 1003 persons related to these heterozygotes were examined and a total of 432 heterozygotes were diagnosed (241 AS, 140 AT and 51 AC), added to 13 patients with chronic hemolytic anemia (8 SS, 3 SC, 1 TT and 1 CC) and 16 risk couples, made up of two heterozygotes. The examination percentages of pregnant women (100 per cent), newly born children (75 per cent), other children (97 per cent), husbands (56 per cent ) and other relatives (64 per cent) showed the high rate of acceptance of the program in the community. Genetic counselling was accepted by 60 per cent of the heterozygotes over 15 years of age.
Asunto(s)
Humanos , Masculino , Femenino , Embarazo , Recién Nacido , Lactante , Preescolar , Niño , Adolescente , Adulto , Asesoramiento Genético , Planes y Programas de Salud , Hemoglobina C/análisis , Hemoglobina Falciforme/análisis , Hemoglobinopatías/sangre , Heterocigoto , Anemia de Células Falciformes/sangre , Talasemia beta/sangre , Brasil , Enfermedad Crónica , Enfermedad de la Hemoglobina C/sangre , Diagnóstico Prenatal , Muestreo Aleatorio SimpleRESUMEN
As concentraçöes de hemoglobina fetal de 42 indivíduos com estigma para hemoglobina C e de cinco indivíduos com homozigose para hemoglobina C foram confrontadas com as concentraçöes de hemoglobina fetal de 47 indivíduos com homozigose para hemoglobina A. Os estigmas e homozigotos para hemoglobina C foram pareados com os homozigotos para hemoglobina A, através de sexo, idade, dosagem de hemoglobina total e hematócrito. Os homens com estigma para hemoglobina C (81,8%) apresentaram valores de hemoglobina fetal acima de 1% de anemia discreta, o mesmo näo se verificando com as mulheres com estigma para hemoglobina C
Asunto(s)
Lactante , Preescolar , Niño , Adolescente , Adulto , Persona de Mediana Edad , Humanos , Masculino , Femenino , Anemia/sangre , Hemoglobina Fetal/análisis , Hemoglobina C/análisisRESUMEN
Säo analisados os resultados do hemograma de 990 indivíduos sem queixas clínicas, com homozigose para hemoglobina A (AA), com estigma para falcemia (AS) e com estigma para hemoglobina C (AC). Os estigmas para hemoglobina S têm hemotócrito, hemoglobina e contagem de hémacias com valores diferentes dos indivíduos AA. Os AC apresentam para estes mesmos exames valores semelhantes aos dos AA. Na contagem global de leucócitos näo existem diferenças significativas entre os AA, AS e AC