RESUMEN
Objetivou-se avaliar o processo de adaptação de idosos que buscam, voluntariamente, residir em Instituição de Longa Permanência para Idosos (ILPI), na cidade de Fortaleza-CE, com base no modelo teórico de Roy. Pesquisa descritiva, realizada em uma IPLI com treze idosos residentes. A coleta de dados foi por meio de entrevista, nos meses de outubro e dezembro de 2011. Os dados foram tratados pela análise de conteúdo temática. Emergiram as seguintes temáticas: Eu Físico, subdividido em sensação corporal e imagem corporal; e Eu Pessoal, subdividido em auto coerência, auto ideal e ser moral-ético-espiritual. Assim, a opção de morar em ILPI não mudou efetivamente a vida dos idosos. Estes conseguiram adaptação ao local e convivem bem com os estímulos internos e externos.
This study aimed to evaluate the adaptation of elderly individuals voluntarily reside in Institution for the Aged (LTCF) in the city of Fortaleza-CE, based on the theoretical model of Roy. Descriptive study, in a IPLI involving thirteen elderly residents. Data collect was through interviews in the months of October and December 2011 and organized by thematic content analysis. The following themes has emerged: I Physical subdivided into body sensation and body image; Staff and I, subdivided into self-consistency and auto ideal be moral-ethical-spiritual. Thus, the option to live in ILPI not effectively changed the lives of elderly people. They managed to adapt to the local and coexist well with internal and external stimuli.
Este estudio tuvo como objetivo evaluar la adaptación de las personas mayores que residen voluntariamente en la Institución para la tercera edad (LTCF) en la ciudad de Fortaleza-CE, basado en el modelo teórico de Roy. Estudio descriptivo, en un IPLI con trece ancianos residentes. Los datos fueran recogidos a través de entrevistas en los meses de octubre y diciembre de 2011 y organizados mediante análisis de contenido temático. Emergieron los siguientes temas: subdivide I Física en la imagen corporal y sensación de cuerpo; El personal y yo, subdividen en auto-consistencia y auto ideal ser moral-ético-espiritual. Por lo tanto, la opción de vivir en ILPI no cambió de manera efectiva la vida de los ancianos. Se las arreglaron para adaptarse a lo local y convivir bien con los estímulos internos y externos.
Asunto(s)
Animales , Masculino , Conejos , Tronco Encefálico/efectos de los fármacos , Indenos/farmacología , Micotoxinas/farmacología , Tronco Encefálico/fisiología , Diazepam/farmacología , Estimulación Eléctrica , Neuronas Motoras/efectos de los fármacos , Formación Reticular/efectos de los fármacosRESUMEN
Background & objectives: The severe toxicity, exorbitant cost and emerging resistance of Leishmania species against most of the currently used drugs underscores the urgent need for the alternative drugs. The present study evaluates in vitro anti-leishmanial activity of Plumeria bicolor and its isolated compounds. Methods: The in vitro anti-parasitic activity of chloroform extract of Plumeria bicolor, plumericin and isoplumericin were tested alongwith appropriate controls against promastigote and amastigote forms of Leishmania donovani using 96 well microtiter plate. The concentration used for assessing the anti-leishmanial activity of extract of Plumeria bicolor and both isolated compounds were 100 μg/ml and 15 μM, respectively. The viability of the cells was assessed by MTT assay. The cytotoxicity of these compounds was performed against J774G8 murine macrophage cells lines at the concentration of 30 μM. Results: The Plumeria bicolor extract showed activity with the IC50 of 21±2.2 and 14±1.6 μg/ml against promastigote and amastigote forms of L. donovani, respectively. Plumericin consistently showed high activity with the IC50 of 3.17±0.12 and 1.41±0.03 μM whereas isoplumericin showed the IC50 of 7.2±0.08 μM and 4.1±0.02 μM against promastigote and amastigote forms, respectively. Cytotoxic effect of the chloroform extract of P. bicolor, plumericin and isoplumericin was evaluated in murine macrophage (J774G8) model with CC50 value of 75±5.3 μg/ml, 20.6±0.5 and 24±0.7 μM, respectively. Interpretation & conclusions: Our results indicated that plumericin showed more potent activity than isoplumericin and might be a promising anti-leishmanial agent against L. donovani.
Asunto(s)
Animales , Antiparasitarios/farmacología , Apocynaceae/química , Línea Celular , Humanos , Indenos/farmacología , Concentración 50 Inhibidora , Iridoides/farmacología , Leishmania/efectos de los fármacos , Leishmania/parasitología , Leishmania donovani/efectos de los fármacos , Leishmania donovani/patogenicidad , Macrófagos/citología , Ratones , Extractos Vegetales/farmacologíaRESUMEN
A series of indan-1 acids were synthesized and screened for anti-inflammatory activity. All the reported compounds showed varying degrees of anti-inflammatory activity in carrageenin-induced paw oedema test. They also exhibited appreciable antipyretic and analgesic activity in various animal test models. Among these compounds 6-methoxy-indan-1-acetic acid (compound 11) and 5,6-dimethoxy-indan-1-acetic acid (compound 12) showed activity profile close to that of phenylbutazone having prolonged action and lower toxicity than the latter.