Ocular Malignancies; lactate dehydrogenase levels in aqueous humour and serum of patients

A total of 50 cases with clinical diagnosis of ocular malignancy were studied for lactate dehydrogenase [LDH] levels in aqueous humour and serum. On histological examination, 40 cases were those of retinoblastoma, 7 had other types of ocular malignancies [squamous cell carcinoma 5, one each of malignant melanoma and sebaceous carcinoma]., whereas three turned out to be non-malignant. Aqueous LDH levels were significantly raised [P< 0.001] in cases of retinoblastoma when compared to other malignancies as well as controls. Mean aqueous humour to serum LDH ratios were also significantly raised [P<0.001] in cases of retinoblastoma