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Acta cir. bras ; 29(10): 667-674, 10/2014. tab, graf
Artículo en Inglés | LILACS | ID: lil-725291

RESUMEN

PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. .


Asunto(s)
Adulto , Anciano , Animales , Femenino , Humanos , Persona de Mediana Edad , Adulto Joven , Cadherinas/análisis , Carcinoma de Células Escamosas/patología , Lesiones Intraepiteliales Escamosas de Cuello Uterino/patología , Neoplasias del Cuello Uterino/patología , Cervicitis Uterina/patología , Biopsia , Estudios Transversales , Cadherinas/metabolismo , Carcinogénesis/metabolismo , Carcinoma de Células Escamosas/metabolismo , Inmunohistoquímica , Valores de Referencia , Lesiones Intraepiteliales Escamosas de Cuello Uterino/metabolismo , Biomarcadores de Tumor/análisis , Neoplasias del Cuello Uterino/metabolismo , Cervicitis Uterina/metabolismo
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