Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
1.
Tunisie Medicale [La]. 2008; 86 (2): 118-121
en Francés | IMEMR | ID: emr-90565

RESUMEN

Hairy cell leukemia is a rare lymphoproliferative disorder. With cytological and immunophenotypic features. We report 6 cases of hairy cell leukemia diagnosed in the Biological Department of Hematology at the Aziza Othmana Hospital of Tunis. Hairy cells was observed in blood smears of 5 cases. Flow cytometry analysis shown a monoclonal population B while gatinting on the expression of the CD19 and SSC signal. The positivity of the CD 103 is noted in 5 cases and the CD11c signal is intense in all the cases. Immunophenotype is of great interest in the diagnosis of hairy cell leukemia


Asunto(s)
Humanos , Masculino , Femenino , Leucemia de Células Pilosas/inmunología , Biología Celular , Inmunofenotipificación , Citometría de Flujo , Antígenos CD19 , Antígenos CD , Cadenas alfa de Integrinas , Antígeno CD11c
2.
Indian J Pathol Microbiol ; 2005 Jul; 48(3): 387-9
Artículo en Inglés | IMSEAR | ID: sea-75301

RESUMEN

Hairy-cell leukemia-variant (HCL-V) is a rare B-cell disorder which accountsfor 10% of HCL cases. The main features are splenomegaly, lymphocytosis and cytopenias without monocytopenia. The circulating cells have a morphology intermediate between prolymphocytes and hairy cells. The immunophenotype shows a mature B-cell phenotype with expression of B-cell antigens CD11c and CD103 but unlike typical hairy cell the cells are negative for CD25. The histology of bone marrow and spleen shows a pattern of infiltration similar to that in HCL. We present a case of HCL-V in a 66-year-old male. The bone marrow findings, immunophenotypic profile and electron microscopic features are described. The patient underwent splenectomy which also revealed infiltration by leukemia. Patients are resistant to alkylating agents and alpha-interferon (á-IFN). Splenectomy may be beneficial for long-lasting partial responses in some of the patients and is a good palliative treatment.


Asunto(s)
Anciano , Antígenos CD/metabolismo , Antígeno CD11c/metabolismo , Linfocitos B/inmunología , Médula Ósea/patología , Neoplasias de la Médula Ósea/inmunología , Humanos , Inmunofenotipificación , Cadenas alfa de Integrinas/metabolismo , Leucemia de Células Pilosas/inmunología , Masculino , Bazo/patología , Neoplasias del Bazo/inmunología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA