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1.
Mem. Inst. Oswaldo Cruz ; 109(5): 577-588, 19/08/2014.
Artículo en Inglés | LILACS | ID: lil-720420

RESUMEN

Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.


Asunto(s)
Animales , Humanos , Ratones , Eritrocitos/parasitología , Malaria Cerebral/fisiopatología , /metabolismo , Barrera Hematoencefálica/parasitología , Circulación Cerebrovascular , Modelos Animales de Enfermedad , Endotelinas/metabolismo , Interacciones Huésped-Parásitos , Malaria Cerebral/parasitología , Óxido Nítrico/metabolismo , Vasoconstricción/fisiología
2.
Mem. Inst. Oswaldo Cruz ; 101(5): 523-528, Aug. 2006. ilus, graf, tab
Artículo en Inglés | LILACS | ID: lil-437036

RESUMEN

Immune responses to malaria infections are characterized by strong T and B cell activation, which, in addition of potentially causing immunopathology, are of poor efficacy against the infection. It is possible that the thymus is involved in the origin of immunopathological reactions and a target during malaria infections. This work was developed in an attempt to further clarify these points. We studied the sequential changes in the thymus of CBA mice infected with Plasmodium berghei ANKA, a model in which 60-90 percent of the infected animals develop cerebral malaria. During the acute phase of infection, different degrees of thymocyte apoptosis were recorded: (1) starry-sky pattern of diffuse apoptosis with maintenance of cortical-medullary structure; (2) intense apoptosis with cortical atrophy, with absence of large cells; (3) severe cortical thymocyte depletion, resulting in cortical-medullary inversion. In the latter, only residual clusters of small thymocytes were observed within the framework of epithelial cells. The intensity of thymus alterations could not be associated with the degree of parasitemia, the expression of clinical signs of cerebral malaria or intensity of brain lesions. The implications of these events for malaria immunity and pathology are discussed.


Asunto(s)
Animales , Femenino , Ratones , Apoptosis/inmunología , Malaria Cerebral/inmunología , Malaria Cerebral/parasitología , Plasmodium berghei/fisiología , Timo/inmunología , Modelos Animales de Enfermedad , Depleción Linfocítica , Ratones Endogámicos CBA , Malaria Cerebral/patología , Parasitemia , Índice de Severidad de la Enfermedad , Factores de Tiempo , Timo/patología
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