RESUMEN
Meningitis, an inflammation of covering of brain and spinal cord that can occur at any age, but when it occurs in new born babies, it is called neonatal meningitis. Escherichia coli (E.coli) are a common cause of meningitis in new born and associated most frequently with prematurity. E.coli meningitis can be acquired during birth or can develop secondarily after infection in another body site such as upper respiratory tract infection, omphalitis or infected circumcision wound. Patient was treated successfully with i.v Ceftriaxone.
Asunto(s)
Infecciones por Escherichia coli , Humanos , Recién Nacido , Meningitis por Escherichia coli/tratamiento farmacológico , Meningitis por Escherichia coli/epidemiología , Meningitis por Escherichia coli/etiología , Meningitis por Escherichia coli/microbiologíaRESUMEN
We evaluated the efficacy of non-competitive N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) as an adjuvant therapy in experimental neonal bacterial meningitis. Meningitis was induced by injecting 10(6) colony forming units of Escherichia coli into the cisterna magna. MK-801 3 mg/kg was given as a bolus intravenous injection, 30 min before the induction of meningitis. MK-801 did not down-modulate the inflammatory parameters, such as increased intracranial pressure, cerebrospinal fluid (CSF) leukocytosis, increased lactate and TNF-alpha levels in the CSF, and hypoglycorrhachia observed in the meningitis group. MK-801 did not significantly attenuate the elevated glutamate concentration in the CSF. However, MK-801 showed some neuroprotective effects as evidenced by significant attenuation of cerebral lipid peroxidation products (conjugated dienes) and increase of brain high-energy phosphate compounds (ATP and PCr). Improvement in cerebral cortical cell membrane Na+, K+ -ATPase activity did not reach a statistical significance. These results suggest that MK-801 was effective in ameliorating brain injury in neonatal bacterial meningitis, although it failed to attenuate the inflammatory responses.
Asunto(s)
Animales , Animales Recién Nacidos , Glucemia/metabolismo , Encéfalo/citología , Encéfalo/efectos de los fármacos , Encéfalo/metabolismo , Membrana Celular/efectos de los fármacos , Membrana Celular/metabolismo , Corteza Cerebral/metabolismo , Maleato de Dizocilpina/farmacología , Metabolismo Energético , Antagonistas de Aminoácidos Excitadores/farmacología , Ácido Glutámico/líquido cefalorraquídeo , Ácido Láctico/sangre , Leucocitos/metabolismo , Meningitis por Escherichia coli/tratamiento farmacológico , Meningitis por Escherichia coli/metabolismo , Neuronas/efectos de los fármacos , Neuronas/metabolismo , Fármacos Neuroprotectores/farmacología , Distribución Aleatoria , Porcinos , Factor de Necrosis Tumoral alfa/líquido cefalorraquídeoRESUMEN
The authors report on a case of neonatal meningitis caused by a strain of E. coli K1. The interest of rapid technics for detection of bacterial antigens is emphasized and the place of third generation cephalosporins discussed