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Indian J Exp Biol ; 1994 Jun; 32(6): 405-8
Artículo en Inglés | IMSEAR | ID: sea-60011

RESUMEN

Experimental myositis was induced in guinea pigs by multiple inoculations with Myosin B fraction of the rabbit skeletal muscle. Quantitative histopathological features were studied and they include necrosis, central nucleation, inflammatory cellular reaction. Besides myositis, features of myocarditis were evident in 40% animals. Circulating immune complexes (CICs) in the sera of experimental animals were isolated by a polyethylene glycol (PEG) precipitation method. Presence of antimyosin B antibody in the immune complexes was characterised by an enzyme-linked immunosorbent assay. The role of circulating immune complexes in pathogenesis of experimental myositis and human polymyositis have been emphasised.


Asunto(s)
Animales , Complejo Antígeno-Anticuerpo/inmunología , Cobayas , Inmunización , Masculino , Microscopía/métodos , Músculo Esquelético/efectos de los fármacos , Miosinas/farmacología , Miositis/inmunología
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