Asunto(s)
Adolescente , Niño , Preescolar , Resistencia a Medicamentos , Femenino , Estudios de Seguimiento , Mesangio Glomerular/inmunología , Glomerulonefritis/inmunología , Glomeruloesclerosis Focal y Segmentaria/inmunología , Glucocorticoides/uso terapéutico , Humanos , Inmunoglobulina M/análisis , Masculino , Nefrosis Lipoidea/inmunología , RecurrenciaRESUMEN
Serum immunoglobulin concentrations were determined in eighteen patients with minimal change nephrotic syndrome. Serum IgG and IgA were significantly decreased; whereas IgM was significantly increased in majority of the cases. Eight of the eighteen patients were treated with steroids. All the eight patients showed a significant increase in serum IgG and a decrease in IgM in response to steroid therapy. The increased serum IgM and decreased IgG before treatment and their restoration to normal levels after steroid therapy may suggest a possible defect in T-cell function.
Asunto(s)
Adolescente , Corticoesteroides/uso terapéutico , Adulto , Proteínas Sanguíneas/análisis , Femenino , Humanos , Inmunoglobulinas/análisis , Masculino , Nefrosis Lipoidea/inmunología , Proteinuria/tratamiento farmacológico , Linfocitos T/inmunologíaRESUMEN
Association of HLA antigens with certain diseases provide insights into genetically determined susceptibility to disease. Although nephrotic syndrome is one of the commonest diseases, it is poorly understood. A group of 57 patients suffering from a minimal lesion nephrotic syndrome (33 patients) and mesangioproliferative glomerulonephritis (24 patients) was studied for immunologic markers. The incidence of HLA-A w 24 is significantly greater in the minimal lesion nephrotic syndrome patients than in controls (18.7% in patients, 0% in controls, p < 0.01). This report fails to show a high incidence of specific HLA antigen in mesangioproliferative glomerulonephritis patients. We believe that the high incidence of HLA-Aw 24 in minimal lesion nephrotic syndrome is indicative of a congenital predisposition to nephrotic syndrome.