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1.
Braz. j. med. biol. res ; 29(2): 239-44, Feb. 1996. graf
Artículo en Inglés | LILACS | ID: lil-161676

RESUMEN

We have investigated different experimental schedules to achieve adherence of Neisseria meningitidis group B to cultured and buccal epithelial cells (BEC) and the effect of antibodies and receptor analogues on bacterial adherence. No adherence of meningococcus was observed when HeLa, HEp-2 or KB cells were used, but high rates of adherence to BEC occurred. The effect of antibodies on bacterial adherence was studied in assays carried out in the presence of saliva and serum collected from convalescing children with meningococcal meningitis and children vaccinated with VAMENGOC B-C. Both saliva and serum from the convalescent patients inhibited the adherence of meningococci, but saliva and serum from vaccinated children did not, corroborating our previous data of a poor antibody response induced by this vaccine. Human colostrum did not affect meningococcal adherence despite the presence of antibodies to N. meningitidis detected by ELISA. Inhibition of adherence by sera from an immunized horse, rabbits and mice, as well as by cell receptor analogues (outer-membrane complex and purified polysaccharide C), was observed. Our results show that up to now BEC continue to be the best cells to study meningococcal adherence and the effect of adherence inhibitors.


Asunto(s)
Humanos , Adhesinas Bacterianas/inmunología , Anticuerpos Antibacterianos/farmacología , Técnicas In Vitro , Neisseria meningitidis/inmunología , Vacunas Bacterianas/administración & dosificación , Vacunas Bacterianas/inmunología , Técnicas de Cultivo de Célula , Nasofaringe/microbiología , Neisseria meningitidis/fisiología
2.
Mem. Inst. Oswaldo Cruz ; 81(4): 453-7, Oct.-Dec. 1986. ilus, tab
Artículo en Inglés | LILACS | ID: lil-39853

RESUMEN

As secreçöes nasais de voluntários colonizados por N. lactamica inibem a aderência de N. Lactamica e de meningococos dos grupos A e B à células oroepiteliais humanas, "in vitro". A aderência, nas amostras de Neisseria testadas, decorre da presença de adesinas näo-fimbriais que parecem possuir antígenos comuns. A despeito do surgimento de marcante atividade antiadesiva nas secreçöes nasais os voluntários persistiram como portadores de N. lactamica. A erradicaçäo do estado de portador parece assim ser dependente da açäo de diferentes fatores


Asunto(s)
Adulto , Humanos , Mucosa Nasal/metabolismo , Nasofaringe/microbiología , Neisseria meningitidis/fisiología , Neisseria/metabolismo , Nasofaringe/citología
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