RESUMEN
A 40-year-old previously healthy lady presented with nasal obstruction and localized plaques over the right arm. She developed complete nasal obstruction due to a mass in the right nasal cavity and skin lesions that ulcerated to present as ecthyma gangrenosum like lesions. Patient's condition deteriorated fast and she developed icterus with fatal outcome within 4 weeks of developing skin lesions. Nasal and skin biopsy revealed angiocentric T-cell lymphoma, which on immuno-phenotyping revealed CD-3 positive; and CD-20, CD-30, ALK and EMA negativity. She was seronegative for HIV. Final diagnosis of CD-3 positive extranodal T-cell lymphoma of nasal type was made. Extranodal T-cell lymphomas are very aggressive NHLs with poor prognosis. Prognosis depends on histology, stage of the disease and sites of involvement. NK/T cell lymphoma of nasal type is common with EBV association. Skin involvement is rare and is also an indicator of poor prognosis.
Asunto(s)
Adulto , Complejo CD3/metabolismo , Ectima/patología , Resultado Fatal , Femenino , Humanos , Linfoma de Células T/etiología , Neoplasias Nasales/etiología , Neoplasias Cutáneas/etiologíaRESUMEN
OBJETIVO: Analisar os aspectos tomográficos dos tumores malignos da cavidade nasal. MATERIAIS E MÉTODOS: Foram estudados 18 pacientes - dez homens e oito mulheres - com tumor da cavidade nasal, os quais realizaram tomografia computadorizada da face. RESULTADOS: Dos tumores, seis eram casos de carcinoma epidermóide, três melanomas, dois carcinomas adenóides císticos, um adenocarcinoma polimórfico de baixo grau, um carcinoma indiferenciado, um carcinoma neuroendócrino, um linfoma não-Hodgkin, um rabdomiossarcoma alveolar, um sarcoma fusocelular grau II e um estesioneuroblastoma. As lesões foram mais freqüentes (p > 0,05) no lado esquerdo e no andar médio. CONCLUSÃO: Os carcinomas epidermóides apresentam grau de destruição correspondente ao seu volume, semelhante aos tumores epidermóides de outros sítios. O septo nasal foi acometido de maneira diferente, de acordo com os tipos histológicos.
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Carcinoma de Células Escamosas , Cavidad Nasal/patología , Neoplasias Nasales , Neoplasias Nasales/etiología , Brasil , Estudios Transversales , Diagnóstico Diferencial , Neoplasias Nasales/patología , Tomografía Computarizada por Rayos XRESUMEN
Comunicamos 5 pacientes con epiteliomas basocelulares consecutivos a cicatrices. Las formas clínicas fueron ulceradas en 4 de ellos, con histopatologías de epiteliomas basocelulares cordonados. El restante, noduloide, presentó un aspecto lobulado. Las cicatrices fueron consecutivas a: 2 casos por quemadura (metal incandescente y solvente), 2 a traumatismo y 1 post-vacunación antivarióla. El período entre el trauma y la aparición del tumor fue de 24 años promedio. Los 5 tumores se desarrollaron en áreas expuestas. Se realizó terapéutica en totalidad de los casos, con buenos resultados y seguimiento de más de 1 año, sin recaída
Asunto(s)
Humanos , Carcinoma Basocelular/etiología , Cicatriz/complicaciones , Neoplasias Faciales/etiología , Neoplasias Nasales/etiología , Neoplasias Cutáneas/etiología , Brazo , Cicatriz/etiología , Cuero CabelludoRESUMEN
Olfactory neuroblastoma is a rare neurogenic tumour of olfactory epithelium. We have dealt with seven cases in nine years. It mainly occurs in adolescents or adult age. It is more common in males presenting with nasal obstruction epistaxis, numbness of face. The tumour is deceptive even under microscope and should be carefully recognised. It is radio sensitive but combination of surgery and radiotherapy seem to give better and longer regression of the tumour. Chemotherapy plays a palliative role only