Epidemiological Profile of 96 Intracranial Tumors Treated in a Single Reference Center

Objectives The present study aims to categorize the prevalence of intracranial tumors surgically treated at the neurosurgery service of Hospital Universitário Evangélico Mackenzie (HUEM) between 2016 and 2018. Material and Methods This survey included patients surgically treated due to primary or metastatic intracranial neoplasia between 2016 and 2018 at a referral center in the city of Curitiba. These patients were analyzed for epidemiological, histopathological, and topographic data, and they underwent an assessment of the outcome at the time of hospital discharge. Results Atotal of 96patientsmet the inclusion criteria. Themost prevalent tumorwas the glioma, with 39.6% of the sample, with glioblastoma being themost prevalent histological type. Brainmetastases andmeningiomas represented, respectively, 21.9%and 18.8%of the total. There was a predominance of supratentorial and intra-axial tumors in our sample. Conclusion Glioma was the most commonly found tumor, directly associated with high morbidity and mortality. The development of new and more effective drugs with action directed at themolecular level of intracranial tumorsmay be the path to a longer survival and improvement in the quality of life of these patients.

Epileptic seizures in supratentorial gliomas.

Two hundred patients with supratentorial glioma; astrocytoma (pilocytic, fibrillary, gemistocytic) 82, mixed glioma (oligoastrocytoma) 46, oligodendroglioma 8, malignant (anaplastic) astrocytoma 33 and glioblastoma multiforme 31, surgically treated for the tumours and followed up for one to sixteen years, were retrospectively analysed for the incidence of pre and postoperative epileptic seizures. 122 patients (61%) had seizures preoperatively. 62 (50.8%) of them had at least one or more seizures during follow up. Seizures were persistent in 22 patients. Doubtful, or one or two minor seizures occurred in 19 cases. Six patients in this group had seizure only at the time of CT confirmed recurrence, after a seizure free interval of one to nine years. Amongst 78 patients who did not have seizures preoperatively, 24 (30.6%) developed seizures during the postoperative follow up period. Recurrent attacks were reported only by 5 patients while 15 patients had seizure(s) only at the time of recurrence of tumour. Two patients had a few seizures in the early postoperative period and none thereafter, while doubtful seizures were reported by two patients.

Análise retrospectiva da incidência de neoplasias supratentoriais da linha mediana em crianças e jovens: craniofaringeomas, neoplasias da hipótese e pineal / Retrospective analysis of the incidence of supratentorial neoplasms in the median line in children and young patients: craniopharyngiomas, hypophyseal and pineal neoplasms

Analisamos, retrospectivamente, 1.632 casos de neoplasias intracranianas, em um período de 50 anos (1931-1981), do Departamento de Patologia da Faculdade de Medicina da USP, 592 casos (36,2%) eram de indivíduos de 0 a 20 anos, grupo escolhido para este estudo. O total de craniofaringeomas nessa faixa etária foi de 21 casos (3,5%); de neoplasias de hipófise, oito (1,35%); de neoplasias da pineal, quatro (0,6%). Infiltraçöes em hipófise e pineal corresponderam a 24 casos (4,0%); näo houve nenhum caso de metástases. Descriçäo e importância destes achados e comparaçäo com os de outros autores é relatada