Vaginal bleeding in infants caused by endodermal sinus tumours.

We report two cases of vaginal bleeding in infants caused by endodermal sinus tumours of the vagina. The clinical features, diagnostic laboratory investigations and prognosis of this rare paediatric malignancy are discussed.

Pre leukemic granulocytic sarcoma of vagina. A case report with review of literature.

Granulocytic sarcoma is an extramedullary tumor of malignant granulocytic progenitor cells, that may precede the onset of acute myeloid leukemia or appear during the leukemic manifestation or blastic crisis of chronic myeloproliferative disorders. We describe a case of granulocytic sarcoma of vagina in a 27 year old woman treated with local radiotherapy. After seven months of follow up she developed acute myeloid leukemia. The case has been presented in view of its rarity and discussed in light of the available literature.

Câncer de vagina associado a prolapso genital: apresentaçåo de um caso / Carcinoma of vagina associated to genital prolapse in nullipara patient: case report

A associaçåo de câncer priomário da vagina com prolapso genital é uma entidade rara. Os autores apresentam um caso de carcinoma primário de vagina e prolapso genital de terceiro grau em uma paciente mulípara, atendida no Hospital-escola da Faculdade de Medicina do Triângulo MIneiro. Discutiram-se a incidência no serviço e as dificuldades na orientaçåo terapêutica

Adenocarcinoma de células claras de vagina com recorrência fulminante em medula óssea / Clear cell adenocarcinoma of the vagina with bone marrow fulminant recurrence

O adenocarcinoma de células claras de vagina é uma entidade rara, embora sua incidência tenha se elevado em decorrência da exposiçäo intra-uterina das pacientes ao hormônio Dietilestilbestrol. Na maioria dos casos relatados na literatura, o diagnóstico foi feito precocemente, o que concorreu para o bom prognóstico das pacientes. A recidiva, na maioria das vezes, ocorreu locorregionalmente. Näo há relato de acometimento de medula óssea pelo tumor. No presente trabalho, relatamos o caso de uma paciente de 52 anos que apresentou uma recorrência fulminante de um adenocarcinoma de células claras de vagina tratado satisfatoriamente com cirurgia e radioterapia, com acometimento maciço de medula ossea e pancitopenia, o que levou ao óbito por sangramento do SNC. A correlaçäo do aparecimento do tumor com a exposiçäo materna ao Dietilestilbestrol näo pode ser feita.

Primary carcinoma of vagina with uterine prolapse.

Eleven cases of primary carcinoma of vagina were admitted in Kasturba Medical College Hospital during the last 10 years, of which 6 cases aged 44-72 years, were associated with 3rd degree uterine prolapse. All the patients attended the hospital in late stage in spite of having 3rd degree uterine prolapse. Blood stained discharge and ulceration on the prolapsed part, irreducible prolapse with urinary retention and marked oedema of local and surrounding tissues were the presenting symptoms. Lesion on the vagina varied in size from 5 cm to 15 cm. IVP in both the cases of irreducible prolapse and retention of urine revealed hydroureter and hydronephrosis bilaterally. X-ray chest revealed secondaries in one patient only. Histopathology of vaginal biopsy revealed well differentiated squamous cell carcinoma in 5 cases and undifferentiated squamous cell carcinoma in one. Since the patients were in late stage of malignancy and were inoperable, treatment with external telecobalt therapy was undertaken. One patient developed vesicovaginal fistula during the treatment period and another patient developed it at the end of telecobalt therapy.