Cáncer de mama en hombres: revisión de casos en el Hospital Regional de Talca / Breast cancer in men: review of cases at "Hospital Regional de Talca"

Breast cancer in men is a rare pathology. The most common clinical presentation is a palpable and painless retroareolar nodule. In men, it is a rare pathology, there are few studies on the matter, where breast cancer trials frequently exclude men. Objective: to present the incidence of breast cancer in men from the "Regional Hospital of Talca" Method: Retrospective and descriptive study of cases of breast cancer in men who have been treated and followed up in the Breast Pathology Unit of the Regional Hospital of Talca from January 1, 2011 to December 31, 2021.Results: There were 9 cases of breast cancer in men. Average age at diagnosis was 63 years, all patients were 50 years of age or older. One hundred percent of patients consulted for a self-palpable breast nodule. Average size on physical examination was 30 mm. The most frequent histology was invasive ductal carcinoma (56%), followed by invasive tubular carcinoma (22%) and ductal carcinoma in situ (11%). Immunohistochemistry was 100% positive for estrogen and progesterone receptor. Surgery in 56% of cases was total mastectomy with axillary dissection, and in 33% it was total mastectomy alone. 4 patients underwent adjuvant treatment with chemotherapy, and just one required a combination of chemotherapy and radiotherapy. During follow-up, only 2 patients died. Conclusion. Breast cancer in men is not very prevalent and the management is extrapolated from large studies in women, we believe that it is essential to have studies in male patients, to really have clarity on the behavior and evolution of the disease.

Breast cancer in men

Breast cancer in males is a relatively rare entity. In the sub-region, several reports indicate a higher incidence rate compared to other regions in the world. For many years, management strategies were derived from evidence based protocols established for managing female breast cancer. There are however,differences in the epidemiology, presentation, molecular profiles and response to therapies including chemotherapy, hormonal and targeted therapies. Outcomes even though mirroring female breast cancer may actually exhibit differences dependent onstage, race, prognostic and economic variables. The lack of large randomized trials on this subject has resulted in ad hoc management practices across the globe. With new information from renewed interest in the subject, screening and diagnostic guidelines are being established for high-risk groups and we expect to see improvement in outcomes for patients with male breast cancer. This article attempts to bring to light a summary of the current interest, recommendations and controversies in the management of male breast cancer

Histopathological Study of Neoplastic Lesions of Breast.

Aims and Objectives: 1) To study the incidence of various neoplastic lesions of breast. 2) To study the histopathological features of neoplasms and classify them according to WHO classification (2003). 3) To compare the results of study with those of other studies. Materials and Methods: The present study was prospective as well as retrospective which include 252 cases from October 2005 to October 2010. The specimens were received in different forms such as excisional biopsies, modified radical mastectomies, simple mastectomies, tru-cut biopsies, wide local excision and quadrantectomy specimens. Detail gross examination was done for each specimen and histopathological features were studied to classify neoplasms according to WHO classification 2003. Results: Out of total 9086 biopsies, breast biopsies were 366 (4%) during this 5 year study. Total 252 breast neoplasms were studied, where, the incidence of benign neoplasms was 50.4% (127 cases) & for malignant neoplasms was 49.6% (125 cases). Among all types of specimen received, excision biopsy was most common (48%). Upper outer quadrant was most commonly involved region for breast neoplasms. Fibroadenoma, benign phyllodes neoplasm, tubular adenoma, central papilloma, peripheral papilloma, lipoma and neurofibroma were seen among benign neoplasms. While invasive ductal carcinoma not otherwise specified, mixed carcinoma, metaplastic carcinoma, mucinous carcinoma, malignant phyllodes neoplasm, invasive lobular carcinoma, invasive papillary carcinoma, medullary carcinoma, intracystic papillary carcinoma, malignant peripheral nerve sheath neoplasm and collision neoplasm were studied among malignant neoplasms. The most common benign neoplasm was fibroadenoma (87%) and invasive ductal carcinoma not otherwise specified (88%) was malignant neoplasm. Conclusions: Fibroadenoma was the most common (87%) benign breast neoplasm. Among all malignant breast neoplasms, invasive ductal carcinoma, not otherwise specified was most common (88%). In cases of benign neoplasms, the highest incidence was found in the age group of 10-20 years (37%) while in the malignant neoplasms, it was 40 - 60 years (51.2%). The incidence of malignant breast neoplasm in male was 2.4%.

Male breast cancer in Indian patients: Is it the same.

Background: Cancer of the male breast accounts for about 1% of all malignancies in men and 1% of all breast cancers. Poor level of awareness often results in late presentation and delayed diagnosis in our environment. This study was done to analyse the demographic data, management and survival of male breast cancers in Indian subset of patients and compare it with that of western literature. Materials and Methods: A 10 year (2001-2010) retrospective study of all male breast cancers was done. Data regarding the incidence, presentation, histopathology, stage and grade of tumor, management and outcome of patients were analysed. Results: 26 cases of male breast cancer were encountered. This comprised 0.4% of all breast cancers seen in our department during the 10 year period. The ages of patients ranged from 45-75 years with a mean age of 57 years. Family history was present in 4 patients. Clinically, symptoms included self-detected lump in 23 (88.5%) patients, nipple retraction in 12 (46.1%) and pain in 12 (46.1%). All cases were unilateral (16 on right, 10 on left). Disease most commonly involved central quadrant (9 patients). Grade 3 disease was found in 13 patients and Stage 3 disease was most commonly encountered (13 patients). None of our patients received neo adjuvant chemotherapy. 20 (76.9%) patients had modified radical mastectomy and 6 (23.1%) had radical mastectomy. Most of our patients were hormone receptor positive (21 patients). Bilateral orchidectomy, Adjuvant chemotherapy, Adjuvant radiotherapy and Tamoxifen were offered in 3 (11.5%), 16 (61.5%), 17 (65.4%) and 15 (57.7%) patients respectively. Follow up ranged from 1-59 months. Conclusion: Male breast cancer is rare in our centre. Late presentation with advanced disease is a common feature in our environment. Further multiinstitutional, prospective studies are needed for better understanding of management of male breast cancers in Indian subset of patients.

The pathology of breast cancer in Jamaica: the national public health laboratory study / La patología del cáncer de mamas en Jamaica: estudio del laboratorio nacional de salud pública

OBJECTIVE: To document the pathologic features of breast cancer in Jamaica. METHODS: The pathology reports and slides of all patients diagnosed with breast cancer at the National Public Health Laboratory between January 1999 and December 2002 were reviewed. Patient age and gender, side involved, number of tumours identified, tumour size, histologic type, histologic grade, degree of lymph node involvement and parish of origin of the specimens were documented. RESULTS: There were 772 patients, 762 females and 10 males; age range 21 to 96 (mean 57.9 ± 15.9) years. There were 778 specimens (6 bilateral cases), the majority of whom originated from Kingston and St Andrew (34.7%). Manchester (22.9%), St Catherine (13.9%) and St Ann (7.3%) were the next most common sources. The left breast was involved in 50.5% of cases. Gross tumour was identified in 641 (82.4%) specimens, the number of tumours ranging from 1 - 6 (mean 1.1 ± 0.6). The maximum gross tumour dimension ranged from 0.3 to 15 cm (mean 4.1 ± 2.7 cm). Infiltrating duct carcinoma was the predominant histologic type (69.3 %); 13.3%, 49.5% and 37.2 % of all infiltrating tumours were well, moderately and poorly differentiated respectively. In-situ lesions (7.1% of tumours) were all of the ductal phenotype. Axillary lymph nodes were submitted in 296 (38.1%) cases; metastatic disease was identified in 224 (75.7%) of these. The total number of nodes submitted ranged from 1 - 34 (mean 10.8 ± 6.7) with an average of 6.1 (± 5.8) being positive for metastases (range 1 - 29). CONCLUSIONS: The pathologic features of breast cancer documented in this series including average tumour size, histologic types and grade and the degree of lymph node involvement are consistent with patient presentation at relatively advanced stages of disease and highlight the urgent need for public health intervention including a national screening programme.

OBJETIVO: Documentar los aspectos patológicos del cáncer de mamas en Jamaica. MÉTODOS: Se revisaron los reportes y diapositivas de patología de todas las pacientes diagnosticadas con cáncer de mamas en el Laboratorio Nacional de Salud Pública entre enero de 1999 y diciembre de 2002. Se documentaron la edad y el género de los pacientes, el lado afectado, el número de tumores identificados, el tamaño del tumor, el tipo histológico, el grado histológico, el nivel del nódulo linfático, y el distrito de origen de los especimenes. RESULTADOS: Hubo 772 pacientes (762 hembras y 10 varones); el rango de edad 21 a 96 (media 57.9 ± 15.9) años. Hubo 778 especimenes (6 casos bilaterales), la mayor parte de los cuales provenían de Kingston y St Andrew (34.7%). Manchester (22.9%), St Catherine (13.9%), y St Ann (7.3%) fueron las siguientes fuentes más comunes. La mama izquierda estaba afectada en el 50.5% de los casos. El tumor macroscópico se identificó en 641 (82.4%) especimenes, fluctuando el número de tumores de 1 - 6 (media 1.1 ± 0.6). La dimensión máxima del tumor macroscópico osciló de 0.3 a 15 cm. (media 4.1 ± 2.7 cm). El carcinoma ductal infiltrante fue el tipo histológico predominante (69.3%). El 13.3%, 49.5% y 37.2% de todos los tumores infiltrantes estaban bien, moderadamente y pobremente diferenciados respectivamente. Las lesiones in situ (7.1% de los tumores) fueron todas del fenotipo ductal. Nódulos linfáticos axilares fueron sometidos en 296 (38.1%) de los casos; la enfermedad metastática se identificó en 224 (75.7%) de éstos. El número total de nódulos sometidos fluctuó de 1 - 34 (media 10.8 ± 6.7) con un promedio de 6.1 (± 5.8) positivo a las metástasis (rango 1 - 29). CONCLUSIONES: Los aspectos patológicos del cáncer de mamas documentados en esta serie incluyendo el tamaño del tumor, el tipo histológico, y el grado y nivel de afectación del nódulo linfático, concuerdan con la presentación del paciente en etapas relativamente avanzadas de la enfermedad y subrayan la necesidad urgente de la intervención de la salud pública, incluyendo un programa nacional de pesquisaje.

Frequency of breast cancer among sudanese patients with breast palpable lumps.

Background: Breast cancer mortality is high in Sudan and most patients are detected at later stages of the disease due to the lack of awareness and absence of screening programs. This study aimed to determine the pattern and frequency of breast cancer among patients presenting with palpable breast lumps within one year duration. Settings and Design: As a part of the continuous development in cancer management, this descriptive longitudinal study was conducted in Khartoum, Sudan. Methods and Materials: We obtained information (patient's personal data) and Fine-Needle Aspiration (FNA) materials, for occurrence of 200 breast lesions in patients. Statistical Analysis Used: Data were analyzed by using a computer SPSS program. Results: The diagnoses of the 200 breast lesions were as follows: 68 (34%) were malignant, 56 cases (28%) were fibroadenoma, 23 cases (11.5%) were fibrocystic change, 22 cases (11%) were inflammatory lesions (including mastitis and abscess formation), 12 cases (6%) were benign cysts and the remaining 19 patients (9.5%) were with lactation changes (8 cases), lipoma (6 cases), gynecomastia (3 cases) and phyllodes tumor (2 cases). Regarding gender, only 6 patients (0.03%) were males of whom 3 (50%) were diagnosed with gynecomastia. Conclusions: The frequency of advanced breast cancer among patients with breast lesions is high, in this subset of patients, which signals the urgency for implementation of breast screening programs.

Profile of breast cancer patients at a tertiary care hospital in north India.

Background and Aims: We carried out this study in order to know the epidemiology and management strategies for breast cancer patients in our patient population. Settings and Design: The epidemiological data pertaining to demography and risk factors for carcinoma breast were analyzed retrospectively in patients admitted to a tertiary care hospital of North India. Materials and Methods: Hospital records of 304 patients admitted for over a period of five years (January 1998 to December 2002) were used for data analysis. Statistical Analysis Used: Paired T-test . Results: Mean age of our female breast cancer patients was found to be lower compared to the western world, with an average difference of one decade. A majority of the patients were from a rural background and had a longer duration of symptoms compared to urban patients. Lump in the breast was a dominant symptom. Familial breast cancer was uncommon. Left sided breast cancer was slightly preponderant. Screening by mammography and staging procedures such as bone scan, Computed Tomography (CT) scan, and Magnetic Resonance Imaging (MRI) were sparsely used. The most common histology was infiltrating duct carcinoma. Conclusion: Modified radical mastectomy was found to be a safe operative procedure. Breast conservative surgery, although considered the gold standard in early breast cancer, was found unsuitable for our patients, due to the social background and lack of intensive radiotherapy and chemotherapy backup. Infiltrating duct carcinoma was more commonly associated with positive lymph nodes compared to other histopathologies. Cases operated by surgical oncologists had better axillary clearance. Neoadjuvant chemotherapy was used mainly by surgical oncologists suggesting a more rational approach toward the management of breast carcinoma.

Breast diseases in Southern Yemen

To investigate the magnitude of breast diseases, and its frequency distribution in different age groups in Hadramout, Yemen. This is a prospective study conducted at the Central Laboratory of Ibn-Sinna Hospital Hadramout, Yemen from January 2006 to December 2009. Patients attending surgical units for breast problems were eligible. Patients were assessed clinically and referred to the laboratory center to confirm the diagnosis by histopathology. The data were collected from the patients and referral sheets. A total of 635 cases of breast disease were diagnosed. This includes 604 female and 31 male patients. Benign breast diseases [BED] was the most common lesion found in this study comprising 493 cases [77.6%], and 142 [22.4%] comprised malignant cases. Among BBD, the most common lesion was fibroadenoma [40.5%] followed by fibrocystic changes [16%], other benign breast lesions [10%], and inflammatory lesion [8%]. The age groups affected by BBD were: 20-29 years for fibroadenoma; 30-39 years for fibrocystic change; 20-29 years for other benign breast lesions; and 30-39 for inflammatory lesions, and carcinoma of the breast was common in the 40-49 age group. The left breast was affected in 331 [52%] cases, the right in 283 [45%], while in 3%, both breasts were affected. Fibroadenoma was the most frequently diagnosed benign breast lesion in Hadramout. An educational program is needed to alert patients of the significance of breast masses

Epidemiologia do câncer de mama em homens / Epidemiology of breast cancer in men

O presente estudo avaliou os aspectos epidemiológicos, clínicos, diagnósticos e terapêuticos do câncer de mama em homens, cuja ocorrência é rara e poucos relatos são disponíveis na literatura. Foi realizada a pesquisa de artigos científicos publicados sobre esse temático por meio de consultas a bases de dados como BIREME - Biblioteca Virtual em Saúde que possibilita acesso à Lilacs (Literatura Latino-Americanae do Caribe em Ciências da Saúde) e à base de dados PUBMED (Biblioteca Nacional de Medicina dos Estados Unidos). O câncer de mama representa menos de 1% de todos os cânceres em homens, contudo a ocorrência dessa neoplasia tende a aumentar em função da má qualidade de vida e pela dificuldade em efetuar diagnóstico precoce. A incidência aumentou significativamente de 0,86 a 1,06 por 100.000 homens ao longo dos últimos 26 anos; as taxas mais altas ocorrem na América do Norte e na Europa e taxas mais baixas na Ásia. É sabido que os homens com câncer de mama têm as piores taxas de sobre vida global em relação às mulheres, mas esta é provavelmente pela maior idade no momento do diagnóstico, que corresponde à fase mais avançada de apresentação da doença, bem com as maiores taxas de morte por comorbidade de doenças. A prevenção e o diagnóstico precisos são as melhores estratégias para melhorara qualidade de vida e sobrevivência do paciente com essa neoplasia.

Câncer de mama em homem: relato de caso e revisão da literatura / Male breast cancer: a case report and review of the literature

O câncer de mama em homens é uma patologia relativamente incomum. Atinge um homem para cada 1.000 mulheres, representa menos de 1 por cento de todos os cânceres em homens e é responsável por 0,1 por cento da mortalidade por câncer no sexo masculino. Como nas mulheres, o subtipo mais comum é o ductal infiltrativo. No presente trabalho é relatado o caso de um paciente masculino, 67 anos, com nódulo em mama direita com diagnóstico de carcinoma ductal sólido. Apesar de ser incomum, alguns estudos vêm demonstrando um aumento na incidência desses tumores. O exame físico talvez seja a principal ferramenta para o diagnóstico desse tumor. Contudo, a confirmação histopatológica é necessária para avaliação definitiva. Devido à raridade da doença, muitas das atuais modalidades de tratamento são baseadas na experiência com câncer de mama feminino. Este caso evidencia a relevância da conscientização da população sobre essa patologia e ao profissional da saúde em considerar este diagnóstico possível.

Male breast cancer is a fairly uncommon disorder. Affecting only one for a thousand women, it represents less than 1 percent of all male cancers and accounts for 0.1 percent of the male cancer mortality. Just like in women, the most common subtype is the infiltrative ductal. Here we report the case of a 67-year-old male patient with a nodule in the right breast with a diagnosis of solid ductal carcinoma. Although uncommon, a few studies show an increase in the incidence of this tumor. However, histopathologic confirmation is necessary for a definite evaluation. Due to the rarity of the disease, many of the current treatment modalities are based on the experience with female cancer. This case highlights the relevance of raising the awareness of the disease among the general population and health professionals in considering this a potential diagnosis.

Câncer de mama masculino: uma doença diferente / Male breast cancer: a different disease

A câncer de mama em homens é uma doença pouco conhecida e, em razão de sua raridade, existem poucos ensaios clínicos e publicações abordando-o. Nosso objetivo é revisar a literatura focando a epidemiologia, os fatores de risco, a patologia e os marcadores tumorais do câncer de mama em homens. O câncer de mama em homens corresponde a 1% de todas as neoplasias da mama. Os fatores de risco incluem hiperestrogenismo, idade, ascendência judaica, história familiar, síndrome de Klinefelter. Os dados sobre patologia mostram que 90% dos tumores são ductais invasivos, 80% apresentavam receptores de estrógenos e 80% a 90%, receptores de progesterona positivos. O tratamento é extrapolado dos estudos sobre câmcer de mama feminino: cirurgia, hormonioterapia, quimioterapia e radioterapia são usados seguindo os guidelines femininos. Os fatores prognóstico incluem tamanho tumoral, grau histológico e comprometimento linfonodal. O câncer de mama é similar em homens e mulheres; todavia, os casos masculinos apresentam particularidades imunoistoquímicas, mas não existem estudos suficientes para avaliar o impacto dessa característica no prognóstico e tratamento dessa neoplasia.

Breast cancer in men is an unknown disease, because the rarity of the disease precludes large randomized trials and a great number of publications. Our goal is to review of the literature focusing on the epidemiology, risk factors, pathology and molecular markers and treatment of breast cancer in men. Carcinoma of the male breast accounts for 1% of all breast cancers. Risk factors include hiperestrogenism, age, Jewish ancestry, family history, and Klinefelter syndrome. Pathology data reviewed shown: 90% of tumors were invasive ductal carcinoma, 80% of tumors were estrogen receptor positive, 80% to 90% were progesterone receptor positive. Treatment is extrapolated from female studies: surgery, adjuvant hormonal therapy, radiotherapy and chemotherapy, using the same guidelines as for women. Prognostic factors include tumor size, histological grade, and lymph node status. Breast cancer is similar in men and women; however, breast cancer in men has imuno-histochemistry particularities and there is no enough studies regarding the impact of such differences in prognosis, treatments strategies

Clinicopathological study and its prognostic implication in male breast carcinoma.

The aim of the present study is to analyse the cases of male breast carcinoma as regards its incidence, family history, clinical presentation, staging, histopathological grade, hormone receptor status and to identify the prognostic significance of the above factors on the final outcome. Seventy-nine cases of male breast carcinoma were treated in the radiotherapy department of Medical College, Kolkata from 1994-2003 (10 years). The hospital data were used to analyse the epidemiological and clinicopathologic parameters as well as the treatment offered and outcome. Incidence of male breast cancer was 0.6% among all male cancer cases and 2.5% among all breast cases. The median age of presentation was 67 years. Lump in the breast was the commonest presenting feature; 90% had advanced disease at presentation. All patients were treated by mastectomy. Majority received radiotherapy (93%) and chemotherapy (81%) as well. Hormone therapy was given to 83% patients. Five-year disease-free survival was 58% for node negative patients and 47% for node positive patients Two most important prognostic factors that affect the survival were nodal status and tumour size. Male breast carcinoma is a rare disease. Median age of presentation is much higher than the female counterpart. The prognosis and survival is similar but the incidence of positive hormone receptor is much more than breast carcinoma of females. In absence of prospective randomised trial retrospective review data from various centres could provide useful guidelines regarding therapy.

Population-based Breast Cancer Statistics in Korea during 1993-2002: Incidence, Mortality, and Survival

In 2002, breast became the most common cancer site in Korean women. Using national breast cancer incidence data during 1993-2002, crude, age-standardized, and age-specific rates for incidence and mortality were calculated. Survival was examined for cases diagnosed during 1993-2002 and followed up to 2004. Observed survival was calculated using the life table method and relative survival using the Ederer II method. Age-standardized incidence rates in female increased from 14.5 in 1993 to 26.2 per 100,000 in 2002. Age-specific incidences showed peaks in women in their forties. Mortality rates increased from 3.7 in 1993 to 4.6 per 100,000 in 2002 and showed peaks in women in their fifties. Five-year relative survival for female breast cancer diagnosed during 1993-2002 was 82.2%. When we examined the secular trends using cases diagnosed 1993-1999 for complete 5-yr follow-up, the 5-yr relative survival increased from 75.2% in 1993 to 83.5% in 1999. The data from this study will provide valuable information to plan and evaluate actions against breast cancer including national breast cancer screening.

Carcinoma de mama em homem: epidemiologia e tratamento / Male breast cancer: epidemiology and treatment

O câncer de mama no homem é doença rara e corresponde a 0,8% de todos os casos de carcinomas mamários. Ocorre com mais freqüência na sétima década de vida e em geral se apresenta como nódulo indolor localizado em região retroareolar. Os fatores de risco incluem idade, disfunção testicular, doença benigna da mama, história familiar positiva, excesso de exposição a hormônios femininos (síndrome de Klinefelter, drogas), radiação, raça negra, obesidade, elevado nível socioeconômico ou cultural, além de ser mais prevalente em famílias judaicas. A mamografia, a ultra-sonografia e a citologia aspirativa fazem parte dos exames complementares. A mutação do BRCA2 encontra-se associada à maior incidência da doença em homens. Devido à escassa quantidade de tecido glandular, o tratamento-padrão consiste em mastectomia radical modificada, radioterapia e, freqüentemente, quimioterapia. Em geral, os receptores de estrogênio e progesterona são positivos e, ainda hoje, o tamoxifeno é considerado o tratamento hormonal de eleição. O prognóstico é semelhante ao do câncer de mama da mulher, quando se equiparam parâmetros como idade, biologia tumoral e estadiamento.

Male breast cancer (MBC) is a rare disease and accounting for 0,8 % of all cases of breast cancer. Occurs more frequently on 7th decade of life and usually it presents painless subareolar lump. Risk factors include advanced age, testicular dysfunction, benign breast conditions, positive family history, excess exposure to female hormones (Klinefelter's syndrome, drugs), irradiation, black race, obesity, higher socioeconomic or educational status, besides to be more prevalent in Jewish origin. Mammography, sonography and aspiration cytology taken part in the complementary exams. BRCA2 mutation is associated with higher incidence of MBC. Due to the paucity of breast tissue in men, the standard treatment consists of modified radical mastectomy, radiotherapy and frequently chemotherapy. Generally estrogen and progesterone receptors are positives and the tamoxifeno still is the hormonal treatment selectioned. The prognostic is similar to the women breast cancer when to put on a level with parameters like age, biology tumor and stage.

Carcinoma of the male breast: a study of 141 cases from northern Pakistan.

Carcinoma of the male breast, histologically identical to that seen in females, is a rare malignant epithelial tumour. We retrospectively studied 141 cases of male breast carcinoma diagnosed during a ten year period (1992-2001). These tumours comprised 0.7% of all cancers, 1.1% of all malignancies in males and 5.9% of all breast carcinomas in both genders. A male to female ratio of 1:16 was observed. The peak incidence was in the age group between 50-60 years and majority of the patients were below 60 years. Most of the patients presented with a painless lump and infiltrating ductal carcinoma was the main histological type. While compared with our previous similar analysis, a highly significant increase (p< 0.0001) was found for total numbers of breast carcinoma in both sexes and total number of malignancies in males.

Breast cancer in males: a PGIMER experience.

AIM: Male breast cancer is a rare disease representing 1% of all breast cancers and less than 1% of all cancers in men. Because of its rarity, carcinoma breast has not been studied extensively and this prompted us to carry out this retrospective study. The aim of the study was to observe the clinical and pathological features, evaluate the prognostic factors and to co-relate the outcome in patients of male breast cancer. MATERIALS AND METHODS: Thirty patients of male breast cancer treated in the department of radiotherapy from year 1996-2000 were retrospectively analyzed. RESULTS: The actuarial five- year disease free survival was 40%. Three out of 30 i.e. 10% patients had loco-regional recurrence and all of them had locally advanced disease at presentation. Distant metastasis occurred in 9 patients of whom 6 patients had T3-T4 tumor and 1 patient had T1-T2 tumor. CONCLUSION: Modified radical mastectomy followed by external radiation therapy is the standard treatment for male breast cancer. Hormone therapy, as an adjuvant treatment, is the first line approach in a majority of patients and chemotherapy is reserved for patients with poor prognostic factors.