Squamous cell carcinoma of the maxillary sinus: a Tata Memorial Hospital experience.

BACKGROUND: The optimal treatment of maxillary sinus carcinoma remains to be defined and there is a paucity of Indian studies on the subject. AIMS: To present experience of management of squamous cell carcinoma of the maxillary sinus treated with curative intent at a single institution. SETTINGS AND DESIGN: Retrospective study of patients with squamous cell carcinoma of the maxillary sinus who presented between 1994 to 1999. MATERIALS AND METHODS: The records of 73 patients with squamous cell carcinoma of the maxillary sinus were analyzed. Sixty-two patients were evaluable. Forty patients (65%) were treated with surgery followed by postoperative radiotherapy, five patients (8%) were treated with radiotherapy alone, five patients (8%) were treated with surgery alone; 12 patients (19%) received chemotherapy. Statistical analysis used: Statistical analysis was done using Kaplan-Meier method. RESULTS: The majority of patients presented with locally advanced disease (52, 84%); nodal involvement was observed in five patients (8%). The most common site of recurrence was at the primary site, which was observed in 28 patients (45%) and regional failures occurred in 10 (16%). The 3 and 5-year overall survival was 38% and 35% and the disease free survival was 29% and 26% respectively. The 5-year overall survival after surgery and postoperative radiotherapy was 42%. CONCLUSIONS: The majority of patients present with advanced disease resulting in poor outcomes to conventional treatment modalities. Locoregional tumor progression remains a significant pattern of failure. New approaches such as neoadjuvant or concomitant chemoradiotherapy with aggressive surgery need to be considered and evaluated in prospective studies.

Linfoma no Hodgkin de células grandes no hendidas de la cavidad bucal: reporte de un caso / Big-cell non-Hodgkin lymphoma of the oral cavity: report of a case

Los Linfomas No Hodgkin de la cavidad bucal son un grupo representativo de neoplasias que tienen diversidad en antecedentes, manera de presentación, respuesta al tratamiento y pronóstico. Se expone un caso evaluado en el Servicio de Clínica Estomatológica y en el Servicio de Cirugía Bucal de la Facultad de Odontología de la U.C.V., correspondiente a un paciente masculino de 81 años, con lesión de aspecto clínico tumoral en el reborde alveolar superior izquierdo. Basado en el estudio clínico, histopatológico e inmunohistoquímico, fue diagnosticado como Linfoma No Hodgkin de Células Grandes no Hendidas. La conducta a seguir después de realizado el diagnóstico fue, referencia al Hospital Oncológico Luis Razetti en donde le planificaron una combinación de tratamientos (Quimioterapia, Radioterapia)

Intra--arterial chemotherapy in the management of advanced maxillary sinus cancer.

Presented is an update on the current role of intra-arterial chemotherapy in the management of advanced maxillary sinus cancer. The potential benefit of such chemotherapy is that it permits the delivery of a high concentration of the cytotoxic agent directly to the tumour tissue bed in an effort to maximize the cytotoxicity and minimize the side effects. In such circumstances it is feasible to omit mutilating surgery and treat under an organ-sparing protocol without compromising survival.