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1.
Journal of Zhejiang University. Science. B ; (12): 735-738, 2018.
Artículo en Inglés | WPRIM | ID: wpr-1010412

RESUMEN

Neurological injury is a frequent and important complication of coronary artery bypass grafting (CABG). Several risk factors for this type of sequela have been identified, among them aortic arch atherosclerosis. Our previous study indicated that atherosclerotic burden in coronary arteries may likewise predict postoperative neurological complications (Pawliszak et al., 2016b). We assessed the severity of this condition by using the SYNTAX score calculator. However, diagnosing angiographic three-vessel coronary artery disease (3VD) could be an even simpler method of achieving this goal.


Asunto(s)
Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Angiografía Coronaria , Puente de Arteria Coronaria Off-Pump/efectos adversos , Enfermedad de la Arteria Coronaria/cirugía , Proteína Ácida Fibrilar de la Glía/sangre , Proteínas de Neurofilamentos/sangre , Neuropéptidos/sangre , Fosforilación , Estudios Prospectivos , Serpinas/sangre , Neuroserpina
2.
Tanta Medical Sciences Journal. 2008; 3 (2): 66-73
en Inglés | IMEMR | ID: emr-111867

RESUMEN

Neurogenic components, as neurotrophic factors and neuropeptides, are probably involved in the pathogenesis of atopic dermatitis [AD] with the neuroimmunocutaneous system as they modify the functions of immunoactive cells in the skin. Nerve growth factor [NGF] is the best-characterized member of the neurotrophin family. Both NGF and neuropepties may be associated with the disease pathogenesis. The aim of this study is to evaluate the plasma level of NGF and NPs in AD patients and to correlate them with the disease activity and with the nerve changes in the skin by electron microscopy. Plasma levels of NGF and vasoactive intestinal peptide [+VIP] were measured by an immunoenzymatic assay while plasma levels of calcitonine gene related peptide [CGRP] and neuropeptide Y [NPY] were measured by radioimmunoassay in 30 AD patients in comparison to 10 normal non-atopic controls. Electron microscopic study was done in 10 AD patients. It has been found that there is significant increase of plasma levels of NGF and NPs in AD patients compared with controls. There is a positive correlation between the plasma levels of NGF and disease activity [correlation coefficient=0.750, P<0.005]. There is a significant correlation of the number of Schwann axon complex, evidenced by electron microscopic examination and plasma level of NGF in AD patients. Neurogenic factors; NGF and NPs modulate the allergic response in AD, probably through interactions with cells of the immune-inflammatory component. NGF might be considered as a marker of the disease activity


Asunto(s)
Humanos , Masculino , Femenino , Factor de Crecimiento Nervioso/sangre , Neuropéptidos/sangre , Piel/ultraestructura , Microscopía Electrónica , Biopsia
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