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Experimental & Molecular Medicine ; : 536-544, 2012.
Artículo en Inglés | WPRIM | ID: wpr-211933

RESUMEN

It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a causal factor for aging and whether COX-2 inhibitors could prevent aging. We here examined the effect of COX-2 inhibitors on aging in the intrinsic skin aging model of hairless mice. We observed that among two selective COX-2 inhibitors and one non-selective COX inhibitor studied, only NS-398 inhibited skin aging, while celecoxib and aspirin accelerated skin aging. In addition, NS-398 reduced the expression of p53 and p16, whereas celecoxib and aspirin enhanced their expression. We also found that the aging-modulating effect of the inhibitors is closely associated with the expression of type I procollagen and caveolin-1. These results suggest that pro-inflammatory catalytic activity of COX-2 is not a causal factor for aging at least in skin and that COX-2 inhibitors might modulate skin aging by regulating the expression of type I procollagen and caveolin-1.


Asunto(s)
Animales , Ratones , Aspirina/administración & dosificación , Catálisis , Caveolina 1/genética , Colágeno Tipo I/genética , Ciclooxigenasa 2/metabolismo , Inhibidores de la Ciclooxigenasa 2/administración & dosificación , Regulación de la Expresión Génica , Nitrobencenos/administración & dosificación , Pirazoles/administración & dosificación , Envejecimiento de la Piel/efectos de los fármacos , Sulfonamidas/administración & dosificación , Proteína p53 Supresora de Tumor/genética
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