Tumor Phyllodes con transformación a osteosarcoma / Breast osteosarcoma originating in a phyllodes tumor: report of one case

Phyllodes tumors account for less than 1% of tumors of the mammary gland, have both epithelial and stromal components and are classified as benign, borderline and malignant. The malignant tumors are highly heterogeneous: they can differentiate to liposarcomas, fibrosarcomas, rhabdomyosarcomas, chondrosarcomas or osteosarcomas. The differentiation to osteosarcoma is extremely rare, constitutes 1.3% of cases and is very aggressive. The standard treatment of these tumors is surgical. The role of radiotherapy and chemotherapy is not clear. However, in patients in whom wide surgical margins are not achieved, adjuvant radiotherapy can be of help. We report a 63 years old female with a right breast osteosarcoma with an osteoclastic component, originating in a phyllodes tumor. The tumor was excised surgically and afterwards she was treated with 10 sessions of 50 Gy of radiotherapy in 25 fractions. She has remained free of disease for the last 10 months.

Osteosarcoma mandibular osteogénico / Mandibular osteogenic sarcoma

El osteosarcoma es una neoplasia maligna, poco frecuente, que se presenta de forma agresiva y sepuede originar en el hueso de la cavidad oral. Se caracteriza por la producción de osteoide tumoral(trabéculas óseas inmaduras) por parte de las células neoplásicas. Estos tumores suelen formarse en la región metafisiaria de los huesos largos de los miembros, en especial en el fémur y en la tibia. Se presenta el caso clínico de un paciente que concurre al servicio de Estomatología de la Escuela deOdontología, de la facultad de Ciencias de la Salud, Universidad Católica de Córdoba; masculino de 26 años de edad de nacionalidad peruana con diagnóstico clínico de osteosarcoma mandibular, el cual fue tratado con hemisección, quimioterapia y radioterapia en la zona mandibular sector posterior de lado izquierdo con colocación de una placa de titanio en la región.

Osteosarcoma is a malignant, rare and aggressive neoplasm that originates in the bone of the oralcavity. It is characterized by the production of tumor osteoid (immature bone trabeculae) by neoplasticcells. These tumors usually originate in metaphyseal region of long limb bones, especially in femurand tibia.Case report: 26-year-old peruvian male patient attending the Stomatology service at the School ofDentistry, Faculty of Health Sciences, Catholic University of Cordoba. The patient was clinically diagnosedwith mandibular osteosarcoma, treated with hemisection, chemotherapy, radiotherapy onmandibular zone posterior sector of left side and fixation of a titanium bone plate.

Non surgical treatment of sacral osteosarcoma

Osteosarcoma may rarely originate from the axial bones such as pelvis or vertebrae. In some pelvic and most vertebral primary tumors, resection often is not possible completely. In general, these tumors cannot be resected with negative margins so they need additional radiotherapy and chemotherapy, but results are unfavourable because of poor local control and high incidence of distant metastases. This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy. The patient is a 14-year-old boy with a large osteosarcoma tumor in the first sacral vertebral body, with extra skeletal extension. The patient took radiotherapy [6000 centigray] plus chemotherapy regimen consisting of doxorubicin and cisplatin. In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis

Prognostic role of matrix metalloproteinase-9 [MMP-9] in patients with osteosarcoma

Osteosarcoma [OS] is a highly malignant bone tumor and is the most frequent malignant bone tumor in children and adolescents. The majority of patients with this disease harbor "micrometastasis" at diagnosis, a fact that demonstrates the need for molecular variables which can predict the presence or absence of micro-metastasis. Matrix metalloproteinases [MMPs] are a class of matrix - and basement membrane-degrading enzymes whose expression is associated with tumor cell invasive and metastatic behavior. One of these enzymes, MMP-9 is expressed in developing and remodeling bone in OS cell lines. The current study investigated the expression of MMP-9 by immunohistochemistry and its correlation with the prognosis in OS patients treated at Mansoura Clinical Oncology and Nuclear Medicine Department. MMP-9 was examined immunohistochemically using a monoclonal antibody in 20 patients with OS. The range of follow-up was 16 to 53 months with a median of 31.5 months. Correlation of the positivity of staining with prognosis was analyzed with Kaplan-Meier method. We found that MMP-9 immunohistochemical expression was positive in 85% of cases [17/20] and increased MMP-9 expression was significantly associated with poor prognosis in overall, metastasis-free and recurrence-free survivals [p=0.001, 0.001, and 0.002 respectively]. These results suggest that MMP-9 expression is common in OS and demonstrate the correlation of MMP-9 expression and the oncological outcome of OS patients

Resección en bloque y sustitución protésica en paciente con osteosarcoma del extremo proximal de fémur, a dos años de evolución. Informe de un caso / En-Bloq resection and prosthetic substitution in a patient had an osteosarcoma of the proximal femur. A case report after a two year follow-up

Se informa el caso de un paciente de 14 años de edad con diagnóstico de osteosarcoma de metáfisis proximal de fémur tratado con quimioterapia fue sometido a tratamiento quirúrgico con resección en bloque y sustitución protésica. Después de dos años de evolución postoperatoria, el paciente presenta marcha indivial y buenas condiciones generales. Se hace hincapié en una cuidadosa selección del paciente para obtener buenos resultados con este tratamiento