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Indian J Biochem Biophys ; 1996 Jun; 33(3): 218-22
Artículo en Inglés | IMSEAR | ID: sea-27312

RESUMEN

Treatment of bovine pulmonary artery smooth muscle mitochondria with H2O2 stimulated oxidation of GSH and NAD(P)H along with an increase in Ca2+ release. Addition of oxaloacetate to mitochondrial suspension stimulated Ca2+ release and oxidation of NAD(P)H while GSH level remained unchanged. Subsequently, addition of beta-hydroxybutyrate which reduced mitochondrial pyridine nucleotides caused reuptake of the released Ca2+ without causing appreciable alteration of GSH level. Treatment of the mitochondria with 1,3-bis(2-dichloroethyl)-1-nitrosourea (BCNU), an inhibitor of glutathione reductase, significantly decreased GSH level without producing discernible change in Ca2+ release and NAD(P)H oxidation.


Asunto(s)
Animales , Calcio/metabolismo , Carmustina/farmacología , Bovinos , Complejo IV de Transporte de Electrones/metabolismo , Glutatión/metabolismo , Peróxido de Hidrógeno/farmacología , Cinética , Mitocondrias/efectos de los fármacos , Músculo Liso Vascular/metabolismo , NAD/metabolismo , NADP/metabolismo , Oxaloacetatos/farmacología , Oxaloacetatos , Oxidación-Reducción , Arteria Pulmonar/metabolismo
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