RESUMEN
Papaverine hydrochloride is allowed to stand with N-bromosuccinimide [NBS] in acid medium for 30 minutes, where an orange color develops, that absorbs maximally at 391 nm. This method is sensitive over concentration 1-6 mg/100 ml. The reaction of papaverine hydrochloride with NBS was further investigated quantitatively. Direct titration of papaverine hydrochloride with NBS was not successful. However, quantitative determination of papaverine hydrochloride was possible under the condition of back titration. It is suggested that papaverine hydrochloride is broken down into smaller fragments associated with the production of orange color. The methods were applied to the analysis of laboratory prepared mixtures, as well as to pharmaceutical preparations