Methotrexate induced pericarditis and pericardial effusion in psoriatic patient.

We describe a 62-year-old woman with Psoriasis who presented as Methotrexate-induced pericarditis and pericardial effusion. Aspiration of the pericardium was required and the patient made a satisfactory recovery. At six-months follow-up, she remained well, psoriasis plaques was controlled by topical crude coal tar and topical corticosteroid. These complications are extremely rare, but have been described as isolated phenomena associated with methotrexate therapy.

Pericarditis y vasculitis secundarias a la administración de propiltiouracilo / Pericarditis and vasculitis secondary to the administration of propylthiouracil

Se describe un pacientes de 11 años de edad con bocio multinodular hipertiroídeo que después de 26 meses de tratamiento con Propiltiouracilo sufrió una reacción adversa con la droga, con evidencias de pericarditis, vasculitis y granulocitopenia. Los síntomas desaparecieron rápidamente al suspender la droga. Posteriormente fue sometido a tiroidectomía y tratamiento hormonal de reemplazo