RESUMEN
Liver function tests were performed in 61 vivax, 54 malariae and 15 ovale malaria patients who were admitted to Bangkok Hospital for Tropical Diseases between 2001 and 2004. The objective of the study was to evaluate changes in hepatic biochemical indices before and after treatment with artemisinin derivatives. On admission and prior to treatment, hepatic dysfunction was found among the 3 groups. Serum liver function tests and physical examinations were performed weekly during the 28-day follow-up period. Initially elevated serum bilirubin and diminished albumin returned to normal within 2 weeks of treatment. Serum alkaline phosphatase and aminotransferases returned to within normal limits within 3 weeks. We conclude that patients with Plasmodium vivax, P. malariae and P. ovale infections had slightly elevated serum bilirubin, aminotransferase and alkaline phosphatase levels, and hypoalbuminemia. These minor abnormalities returned to normal within a few weeks after treatment with therapies based on artemisinin derivatives.
Asunto(s)
Persona de Mediana Edad , Masculino , Humanos , Femenino , Animales , Adulto , Adolescente , Resultado del Tratamiento , Sesquiterpenos/uso terapéutico , Albúmina Sérica , Plasmodium vivax/efectos de los fármacos , Plasmodium ovale/efectos de los fármacos , Plasmodium malariae/efectos de los fármacos , Malaria Vivax/tratamiento farmacológico , Malaria/tratamiento farmacológico , Pruebas de Función Hepática , Hígado/fisiopatología , Bilirrubina/sangre , Artemisininas/uso terapéutico , Antiinfecciosos/uso terapéutico , Alanina Transaminasa/sangreRESUMEN
Os autores fazem um estudo sobre o tratamento da malária na gestação. Comentam aspectos epidemiológicos e fisiopatológicos da doença e efeitos teratogênicos das drogas.