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Journal of Forensic Medicine ; (6): 349-352, 2006.
Artículo en Chino | WPRIM | ID: wpr-983221

RESUMEN

OBJECTIVE@#To develop a specific, sensitive, reproducible SPE-HPLC method for the determination of 37 drugs in whole blood.@*METHODS@#With the doxapram as internal standard, Oasis column was used to extract drugs from whole blood. Two kinds of mobile phases were used in this study. Separations were achieved by a LiChrospher 100 RP-C18 (250 mm x 4.0 mm x 5 microm) column kept at 50 degrees C, the DAD detector was set at 230 nm and 250 nm.@*RESULTS@#The limit of detection were 1-30 ng/mL. The method showed excellent linearity and the linear correlation coefficient was > or =0.997 98. The relative standard deviation for between-day and within-day assay were <10%.@*CONCLUSION@#The method is effective, simple, reliable and has been used in real cases.


Asunto(s)
Humanos , Cromatografía Líquida de Alta Presión/métodos , Doxapram/aislamiento & purificación , Doxepina/aislamiento & purificación , Estazolam/aislamiento & purificación , Medicina Legal , Morfina/aislamiento & purificación , Papaverina/aislamiento & purificación , Preparaciones Farmacéuticas/aislamiento & purificación , Prazosina/aislamiento & purificación , Procaína/aislamiento & purificación , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Extracción en Fase Sólida/métodos , Solventes/química
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