[Comparison of remifetanil with halothane as the anesthesia maintenance method regarding endoscopic sinus surgery conditions]

Endoscopic surgery is a new standard method of treatment for chronic sinusitis. During this operation even small amount of bleeding may reduce the visual field of surgeon significantly and make the procedure troublesome. In this study we compared the operative conditions between patients who receive either remifentanil or halothane for general anesthesia. Endoscopic sinus surgery was performed in 60 patients. Pre- medication was done by fentanil and midazolam and induction was done by propofol and atracurium. The patients were divided into two groups and received either halothane or remifentanil for anesthesia maintenance. Monitoring was performed during anesthesia. Bleeding volume was measured and operation field condition was assessed by the surgeon. Patients' characteristics such as age and gender were the same in both groups. Intra- operative systolic blood pressure was significantly lower in the remifentanil group but diastolic and mean blood pressure and heart rate didn't change after induction and during maintenance in either group. Recovery time in the remifentanil group was also significantly shorter than the halothane group. Bleeding volume was also lower and the operation field condition was better in the remifentanil group. Remifentanil is a good choice to maintain an ideal anesthesia for endoscopic sinus surgery

Clinical trials on male normotensive subjects and female uti patients treated with the seeds of nigella sativa linn

In the clinical trial to study the effects of KSJ on blood pressure it was noted that KSJ depressed both the systolic and the diastolic blood pressure starting from 1 hour till end of 5 hours after the oral intake of KSJ. But the diastolic pressure was significantly low only from 2 hours after the oral intake of KSJ. All the results of systolic and diastolic pressure are statistically highly significant. In the clinical trail with female UTI patients there was a decrease in pus cells in the urine after the patients were treated with KSJ in comparison to their pre-drug urine examination report

Resultados ergometricos y presurometricos ambulatorios con 1 dosis diaria de 240 mg de diltiazem en hipertensos labiles con ergometria limitrofe / Ambulatory ergometric and pressurometric results with a daily dose of 240 mg of diltiazem in labile hypertensive patients with threshold ergometry

El monitoreo ambulatorio contínuo (MAC) constituye un eficiente elemento de diagnóstico y control terapéutico de la hipertensión arterial (HA). Con la finalidad de evaluar la eficacia y tolerancia de una nueva concentración de diltiazem (240 mg), en comprimidos de liberación programada para una toma diaria, se realizó un estudio doble ciego en 20 pacientes clínicos, electrocardiográficos, ergométricos y de MAC en los períodos basales, placebo y con droga activa. Se observó una diferencia significativa para diltiazem monodosis 240 mg en relación al placebo, en lo que se refiere al descenso de la presión arterial (PA) sistólica y diastólica, no sólo en los controles clínicos sino también durante el MAC tanto en el período diurno como en el nocturno. Esto ocurrió con el promedio de 24 horas y con el porcentaje de registros anormales. En los estudios ergométricos también se observó una diferencia estadísticamente significativa para diltiazem en los siguientes parámetros: tiempo total de la prueba, carga en Kilos, PA sistólica, y desnivel del ST. Se concluye que el diltiazem monodosis 240 mg fue capaz de mantener una eficaz acción antihipertensiva sostenida a lo largo de las 24 horas, con muy buena tolerancia clínica, induciendo una mejoría evidente en la ergtométría y en el MAC, lo que la hace una droga de primera elección en pacientes en los cuales el tratamiento exclusivo de la hipertensión arterial, hasta, ahora, no ha mejorado el pronóstico de la cardiopatia isquémica